Role of Fat Tissue in Vitamin D Metabolism

This study has been completed.
Sponsor:
Collaborator:
Information provided by:
Tufts University
ClinicalTrials.gov Identifier:
NCT00033826
First received: April 10, 2002
Last updated: May 23, 2013
Last verified: May 2013
  Purpose

Vitamin D is a fat soluble vitamin that has important effects on calcium (including absorption of calcium from the diet) and bone metabolism. Vitamin D is known to be stored in fat tissue, and it is also present in the circulation. The purpose of this study is to investigate the relationship between levels of vitamin D in fat tissue and in blood.


Condition
Vitamin D
Adipose Tissue

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: The Role of Adipose Tissue in Vitamin D Metabolism

Resource links provided by NLM:


Further study details as provided by Tufts University:

Enrollment: 41
Study Start Date: April 2002
Study Completion Date: September 2007
Primary Completion Date: September 2007 (Final data collection date for primary outcome measure)
Detailed Description:

Although vitamin D is known to be stored in fat tissue, researchers are not sure about the role that fat tissue plays in vitamin D metabolism. This study will help develop the methodology necessary to further investigate the role of fat tissue in vitamin D metabolism and will assess the relationship between levels of vitamin D in fat tissue and in blood. 50 subjects who are referred for gastric bypass surgery will be enrolled in this study. Subjects will complete questionnaires about their medical history, travel history and food intake. Prior to or during surgery, subjects will be asked to provide a blood sample for selected chemistries related to vitamin D metabolism. During gastric bypass surgery, the surgeon will collect small pieces of fat tissue from the fat under the skin and within the abdomen by surgical biopsy. These samples will be used to refine the methodology for determining the levels of vitamin D in blood and fat tissue and for comparing levels of vitamin D in various tissues.

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

patients from Obesity Clinic

Criteria

Inclusion Criteria:

  • Obese patients referred for gastric bypass surgery

Exclusion Criteria:

  • Patients must not be taking bile acid-sequestering medications or anti-seizure medications
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00033826

Locations
United States, Massachusetts
Tufts-New England Medical Center
Boston, Massachusetts, United States, 02111
Sponsors and Collaborators
Tufts University
Investigators
Principal Investigator: Miriam Blum, MD Jean Mayer USDA Human Nutrition Center on Aging at Tufts University
  More Information

No publications provided

Responsible Party: Miriam Blum, MD, HNRC at Tufts
ClinicalTrials.gov Identifier: NCT00033826     History of Changes
Other Study ID Numbers: K23 AR47869, K23AR047869, NIAMS-070
Study First Received: April 10, 2002
Last Updated: May 23, 2013
Health Authority: United States: Federal Government

Keywords provided by Tufts University:
Vitamin D
Adipose tissue
Metabolism

Additional relevant MeSH terms:
Vitamin D
Vitamins
Micronutrients
Growth Substances
Physiological Effects of Drugs
Pharmacologic Actions
Bone Density Conservation Agents

ClinicalTrials.gov processed this record on September 18, 2014