Cocaine-Metyrapone Interaction Study - 1
Recruitment status was Active, not recruiting
The purpose of this study is to examine the safety of two consecutive days of metyrapone (MRP) in subjects who may use cocaine concurrently.
|Study Design:||Intervention Model: Crossover Assignment
Primary Purpose: Treatment
|Official Title:||Cocaine-Metyrapone Interaction Study|
- Cocaine craving
|Study Start Date:||November 2001|
|Estimated Study Completion Date:||May 2002|
To evaluate the safety of metyrapone (MRP) for using in an outpatient study in which participants would be given 2 750 mg doses of MRP per week. Secondary study goals are to evaluate the possible efficacy of MRP as a treatment for cocaine dependence and to compare 3 factors hypothesized to induce cocaine craving: cocaine cues, stress, and cocaine itself. This study will utilize a Double Blind, placebo-controlled crossover design with 3 factors: 1) medication 2) relapse trigger and 3) infusion for an 11 day in-patient treatment.
|United States, Ohio|
|Cincinnati VA Medical Center|
|Cincinnati, Ohio, United States, 45220|
|Principal Investigator:||Theresa Winhusen, Ph.D.||Cincinnati VA Medical Center|