Does Prophylactic Coronary Artery Revascularization for High Risk Patients Reduce Long-term Risk of Mortality (CARP)

This study has been completed.
Sponsor:
Information provided by:
Department of Veterans Affairs
ClinicalTrials.gov Identifier:
NCT00032370
First received: March 19, 2002
Last updated: May 3, 2011
Last verified: May 2011
  Purpose

Although a number of sophisticated diagnostic tests have been shown to be helpful in identifying patients at high risk for perioperative cardiac complications, no study has addressed the most important question: Should prophylactic coronary revascularization be performed prior to elective vascular surgery? This study is designed to answer this question.


Condition Intervention
Cardiovascular Disease
Procedure: Vascular surgery with best medical treatment
Procedure: Coronary artery bypass grafting (CABG)
Procedure: Percutaneous transluminal coronary angioplasty (PTCA)

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Prevention
Official Title: CSP #411 - The Coronary Artery Revascularization Prophylaxis (CARP) Trial

Resource links provided by NLM:


Further study details as provided by Department of Veterans Affairs:

Primary Outcome Measures:
  • Mortality [ Time Frame: 3 months and 3.5 years post-op ] [ Designated as safety issue: No ]

Enrollment: 510
Study Start Date: August 1997
Study Completion Date: May 2004
Primary Completion Date: February 2004 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
No Intervention: 1
Elective vascular surgery
Procedure: Vascular surgery with best medical treatment
Patients undergo scheduled vascular surgery
2
Cardiac revascularization prior to vascular surgery.
Procedure: Coronary artery bypass grafting (CABG)
Coronary artery bypass grafting prior to vascular surgery
Other Name: CABG
Procedure: Percutaneous transluminal coronary angioplasty (PTCA)
Cardiac revascularization via PTCA prior to vascular surgery
Other Name: PTCA

  Show Detailed Description

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

High risk patients scheduled for elective vascular surgery

Exclusion Criteria:

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00032370

Locations
United States, Arizona
Southern Arizona VA Health Care System, Tucson
Tucson, Arizona, United States, 85723
United States, Arkansas
Central Arkansas VHS Eugene J. Towbin Healthcare Ctr, Little Rock
No. Little Rock, Arkansas, United States, 72114-1706
United States, California
VA Medical Center, San Francisco
San Francisco, California, United States, 94121
VA Greater Los Angeles Healthcare System, West LA
West Los Angeles, California, United States, 90073
United States, Colorado
VA Eastern Colorado Health Care System, Denver
Denver, Colorado, United States, 80220
United States, Florida
North Florida/South Georgia Veterans Health System
Gainesville, Florida, United States, 32608
James A. Haley Veterans Hospital, Tampa
Tampa, Florida, United States, 33612
United States, Georgia
Atlanta VA Medical and Rehab Center, Decatur
Decatur, Georgia, United States, 30033
United States, Indiana
Richard Roudebush VA Medical Center, Indianapolis
Indianapolis, Indiana, United States, 46202-2884
United States, Minnesota
VA Medical Center
Minneapolis, Minnesota, United States, 55417
United States, New Mexico
New Mexico VA Health Care System, Albuquerque
Albuquerque, New Mexico, United States, 87108-5153
United States, North Carolina
VA Medical Center, Durham
Durham, North Carolina, United States, 27705
United States, Ohio
VA Medical Center, Cleveland
Cleveland, Ohio, United States, 44106
United States, Oregon
VA Medical Center, Portland
Portland, Oregon, United States, 97201
United States, Pennsylvania
VA Pittsburgh Health Care System
Pittsburgh, Pennsylvania, United States, 15240
United States, Texas
VA North Texas Health Care System, Dallas
Dallas, Texas, United States, 75216
VA South Texas Health Care System, San Antonio
San Antonio, Texas, United States, 78229
United States, Washington
VA Puget Sound Health Care System, Seattle
Seattle, Washington, United States, 98108
Sponsors and Collaborators
Investigators
Study Chair: Edward O. McFalls, MD Department of Veterans Affairs
  More Information

Publications:

Responsible Party: McFalls, Edward - Study Chair, Department of Veterans Affairs
ClinicalTrials.gov Identifier: NCT00032370     History of Changes
Other Study ID Numbers: 411
Study First Received: March 19, 2002
Last Updated: May 3, 2011
Health Authority: United States: Federal Government

Keywords provided by Department of Veterans Affairs:
myocardial infarction
Prophylactic coronary artery revascularization

Additional relevant MeSH terms:
Cardiovascular Diseases

ClinicalTrials.gov processed this record on July 26, 2014