Effects of St. John's Wort on the Effectiveness of Oral Contraceptives
This study has been completed.
Sponsor:
Information provided by:
National Center for Complementary and Alternative Medicine (NCCAM)
ClinicalTrials.gov Identifier:
NCT00026013
First received: November 5, 2001
Last updated: August 17, 2006
Last verified: July 2006
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Purpose
The purpose of this study is to evaluate the effects of a common herbal remedy, St. John's Wort, on the effectiveness of birth control pills. St. John's Wort has recently been shown to increase metabolism of some drugs. If it could increase metabolism of oral contraceptives as well, it may increase the risk of contraceptive failure and unintended pregnancy. Study participants will be evaluated for risk of ovulation on oral contraceptives before and during simultaneous therapy with St. John's Wort.
| Condition | Intervention |
|---|---|
|
Contraception |
Drug: hypericum perforatum |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Endpoint Classification: Pharmacokinetics/Dynamics Study Intervention Model: Single Group Assignment Masking: Single Blind Primary Purpose: Treatment |
| Official Title: | Effects of Hypericum Perforatum on Effectiveness of Oral Contraceptives |
Resource links provided by NLM:
MedlinePlus related topics:
Birth Control
Drug Information available for:
St. John's Wort
U.S. FDA Resources
Further study details as provided by National Center for Complementary and Alternative Medicine (NCCAM):
Eligibility| Ages Eligible for Study: | 18 Years to 40 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- Women taking or willing to take low dose oral contraceptives for 5 months
- No contraindications to hormonal contraception
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00026013
Locations
| United States, New York | |
| Columbia University Department of Obstetrics & Gynecology | |
| New York, New York, United States, 10032 | |
Sponsors and Collaborators
Investigators
| Principal Investigator: | Patricia Murphy, DrPh | Columbia University |
More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00026013 History of Changes |
| Other Study ID Numbers: | R21 AT000836-01 |
| Study First Received: | November 5, 2001 |
| Last Updated: | August 17, 2006 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Center for Complementary and Alternative Medicine (NCCAM):
|
contraception hormonal contraception herbal remedies hypericum perforatum contraceptive effectiveness |
Additional relevant MeSH terms:
|
Contraceptive Agents Contraceptives, Oral Reproductive Control Agents Physiological Effects of Drugs |
Pharmacologic Actions Therapeutic Uses Contraceptive Agents, Female |
ClinicalTrials.gov processed this record on May 23, 2013