Combination Chemotherapy in Treating Patients With Advanced Cancer

DISEASE CHARACTERISTICS:

• Histologically confirmed progressive malignant disease that has failed at least 1 conventional treatment or is unlikely to respond to current therapy

• Measurable or evaluable disease

  • Elevated serum tumor marker considered evaluable disease

• No known active CNS metastases

  • Previously treated CNS metastases with no evidence of new CNS metastases allowed if stable for at least 2 months

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• ECOG 0-1

Life expectancy:

• More than 3 months

Hematopoietic:

• WBC at least 3,000/mm^3
• Absolute neutrophil count at least 1,500/mm^3
• Platelet count at least 100,000/mm^3
• Hemoglobin at least 10 g/dL (transfusion allowed)
• No active bleeding or coagulation disorder (except occult blood related to gastrointestinal cancer)

Hepatic:

• Bilirubin no greater than 2.0 mg/dL
• ALT and AST no greater than 3 times upper limit of normal (ULN)
• Alkaline phosphatase no greater than 5 times ULN
• PT and PTT no greater than 1.5 times ULN

Renal:

• Creatinine no greater than 1.5 mg/dL

Cardiovascular:

• No active heart disease
• No myocardial infarction within the past 3 months
• No symptomatic coronary artery disease
• No uncontrolled arrhythmias
• No uncontrolled congestive heart failure

Pulmonary:

• No moderate to severe compromise of pulmonary function

Other:

• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No active infectious process
• No pre-existing severe hearing impairment
• No grade 2 or greater neuropathy
• No other life threatening illness
• No prior severe allergic reaction to cisplatin
• No mental deficits and/or psychiatric history that would preclude study
• No persistent chronic toxic effects from prior chemotherapy greater than grade 1

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• At least 2 weeks since prior biologic therapy

Chemotherapy:

• More than 3 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) and recovered
• At least 3 months since prior cisplatin or platinum analogue
• No prior 3-AP

Endocrine therapy:

• At least 2 weeks since prior hormonal therapy

Radiotherapy:

• More than 3 weeks since prior radiotherapy

Surgery:

• At least 3 weeks since prior major surgery and recovered

Other:

• No other concurrent investigational drugs
• No other concurrent nephrotoxic drugs (e.g., aminoglycoside antibiotics)