DISEASE CHARACTERISTICS:

• Histologically confirmed stage IV squamous cell carcinoma of the oral cavity or oropharynx or nodal or dermal metastases for which current available treatment is not likely to offer a survival advantage or result in significant palliation

  • Unresectable locoregional recurrence after maximum radiotherapy OR

  • Local disease with unresectable distant metastases involving:

    • Base of skull
    • Prevertebral fascia
    • Deep neck muscles
    • Carotid artery (requiring resection)
    • Nasopharynx and/or pterygoid muscles
• Ineligible to receive radiotherapy to head and neck during study
• Primary intraoral lesions must be measurable and accessible to intralesional injections
• No metastatic brain lesions, cerebral metastasis, or leptomeningeal disease

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• Zubrod 0-2

Life expectancy:

• At least 2 months

Hematopoietic:

• Absolute neutrophil count greater than 1,000/mm^3
• Platelet count greater than 100,000/mm^3
• Hemoglobin greater than 8 g/dL

Hepatic:

• Bilirubin less than 1.5 mg/dL
• AST/ALT less than 4 times upper limit of normal (ULN)
• PT/PTT less than 1.5 times ULN

Renal:

• Creatinine less than 2.0 mg/dL OR
• Creatinine clearance greater than 60 mL/min

Cardiovascular:

• No evidence of congestive heart failure
• No serious cardiac dysrhythmia
• No evidence of recent prior myocardial infarction on EKG
• No clinical coronary artery disease

Neurologic:

• No history of seizures or concurrent seizure disorder
• No evidence of encephalitis, multiple sclerosis, or other structural brain lesion(s) by clinical or radiological evaluation

Immunologic:

• No risk of immune system compromise
• HIV negative
• No hypersensitivity to eggs
• No significant history of allergies (e.g., anaphylaxis or angioedema)

Other:

• No active or chronic infection
• No other serious concurrent medical illness
• No other malignancy unless previously treated with curative intent and no evidence of persistent or recurrent disease
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• At least 4 weeks since prior immunotherapy and recovered

Chemotherapy:

• No more than 2 prior chemotherapy regimens
• At least 4 weeks since prior chemotherapy and recovered

Endocrine therapy:

• At least 4 weeks since prior systemic corticosteroids
• No concurrent systemic corticosteroids

Radiotherapy:

• See Disease Characteristics
• At least 4 weeks since prior radiotherapy and recovered
• No prior radiotherapy to more than 50% of nodal groups

Surgery:

• More than 4 weeks since prior surgery for primary or metastatic lesions and recovered
• No prior splenectomy