Acitretin in Treating Patients With Skin Disease or Skin Cancer
Recruitment status was Active, not recruiting
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Acitretin may be an effective treatment for skin disease and skin cancer.
PURPOSE: Phase II trial to study the effectiveness of acitretin in treating patients who have skin disease or skin cancer.
|Study Design:||Primary Purpose: Treatment|
|Official Title:||The Evaluation of Oral Acitretin in the Treatment of Psoriasis, Cutaneous Disorders of Keratinization, Multiple Basal Cell Carcinomas and Other Retinoid-Responsive Diseases|
|Study Start Date:||December 2001|
OBJECTIVES: I. Determine the long-term safety and efficacy of acitretin in patients with psoriasis, cutaneous disorders of keratinization, multiple basal cell carcinomas, or other retinoid-responsive diseases or malignancies.
OUTLINE: Patients receive oral acitretin daily in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 130 patients will be accrued for this study.
|United States, Maryland|
|Intramural Research Program|
|Bethesda, Maryland, United States, 20892|
|Study Chair:||John J. DiGiovanna, MD||National Cancer Institute (NCI)|