Biological Aspects of Depression and Antidepressant Drugs

This study has been completed.

First Received on July 3, 2001. Last Updated on January 20, 2009 History of Changes

Sponsor:	Department of Veterans Affairs
Information provided by:	Department of Veterans Affairs
ClinicalTrials.gov Identifier:	NCT00018733

Purpose

This study will be measuring changes in depressive symptoms over a 7 week time period. Double-blind placebo controlled trial using the pharmacologic agents Paroxetine or Desipramine.

Condition	Intervention
Depression	Drug: paroxetine Drug: Desipramine

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Pharmacodynamics Study Masking: Double-Blind Primary Purpose: Treatment
Official Title:	Biological Aspects of Depression and Antidepressant Drugs

Resource links provided by NLM:

MedlinePlus related topics: Antidepressants Depression

Drug Information available for: Desipramine Desipramine hydrochloride Paroxetine Paroxetine hydrochloride Paroxetine hydrochloride hemihydrate Paroxetine Mesylate

U.S. FDA Resources

Further study details as provided by Department of Veterans Affairs:

Study Start Date:	September 1996
Estimated Study Completion Date:	December 2001

Eligibility

Ages Eligible for Study:	21 Years to 69 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Diagnosis of major depressive disorder Ham-D Score > 18
English speaking with ability to read and sign an informed consent

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00018733

Locations

United States, Texas
South Texas Veterans Health Care System
San Antonio, Texas, United States, 78229

Sponsors and Collaborators

Department of Veterans Affairs

Investigators

Investigator:	Steve Brannan, M.D.
Investigator:	Cheryl Gonzalez, M.D.

More Information

No publications provided

ClinicalTrials.gov Identifier:	NCT00018733 History of Changes
Other Study ID Numbers:	MHBS-031-99F
Study First Received:	July 3, 2001
Last Updated:	January 20, 2009
Health Authority:	United States: Federal Government

Keywords provided by Department of Veterans Affairs:

Depression

Additional relevant MeSH terms:

Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders
Antidepressive Agents
Desipramine
Paroxetine
Psychotropic Drugs
Central Nervous System Agents
Therapeutic Uses
Pharmacologic Actions

Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antidepressive Agents, Tricyclic
Adrenergic Uptake Inhibitors
Adrenergic Agents
Neurotransmitter Agents
Neurotransmitter Uptake Inhibitors
Physiological Effects of Drugs
Serotonin Uptake Inhibitors
Serotonin Agents
Antidepressive Agents, Second-Generation

ClinicalTrials.gov processed this record on February 12, 2012