Regulation of Sterol Homeostasis

This study has been completed.
Sponsor:
Information provided by:
Department of Veterans Affairs
ClinicalTrials.gov Identifier:
NCT00018720
First received: July 3, 2001
Last updated: January 20, 2009
Last verified: December 2004
  Purpose

The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol.

This project has two objectives: A) To define the mechanism of impaired bile acid absorption in hypertriglyceridemia (specifically we will determine if the active or passive component of absorption is abnormal) and B) to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol. Because 27-hydroxylase is present in endothelial cells as well as liver, this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque.


Condition
Hypertriglyceridemia

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Regulation of Sterol Homeostasis

Resource links provided by NLM:


Further study details as provided by Department of Veterans Affairs:

Study Start Date: April 1996
Estimated Study Completion Date: December 2000
  Eligibility

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Hypertriglyceridemia and normal controls with normal lipids

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00018720

Locations
United States, Minnesota
VA Medical Center
Minneapolis, Minnesota, United States, 55417
Sponsors and Collaborators
Investigators
Investigator: Norman Javitt, M.D.
Investigator: Alan Hofmann, M.D.
Investigator: Loren Zech, M.D.
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00018720     History of Changes
Other Study ID Numbers: GAST-026-95F
Study First Received: July 3, 2001
Last Updated: January 20, 2009
Health Authority: United States: Federal Government

Keywords provided by Department of Veterans Affairs:
triglyceride
bile acids
cholelithias

Additional relevant MeSH terms:
Hypertriglyceridemia
Dyslipidemias
Hyperlipidemias
Lipid Metabolism Disorders
Metabolic Diseases

ClinicalTrials.gov processed this record on October 23, 2014