Comparison of Daily Nocturnal Hemodialysis With Daily Hemodialysis

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2003 by National Center for Research Resources (NCRR).
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
NCT00012441
First received: March 6, 2001
Last updated: June 23, 2005
Last verified: December 2003
  Purpose

Hemodialysis remains associated with a high mortality (approximately 22% per year) and many complications despite improvements over the last twenty years. Several nephrologists have suggested that increasing the frequency and amount of dialysis will result in improved outcomes. In fact, various forms of daily dialysis have been performed in over 300 patients in the last 30 years with improvements in blood pressure, quality-of-life, bone disease, and other complications of renal failure. Whether this form of treatment can be expanded to the 220,000 Americans on hemodialysis is unknown. The primary outcome of this study is to determine the effectiveness of nocturnal dialysis in hemodialysis patients in St. Louis. If the pilot study is effective, then participation in a larger, multicenter trial is expected. The endpoints measured are use of antihypertensive medications, improvement in secondary hyperparathyroidism and use of phosphorus binders, quality-of-life measured by SF-36 surveys, and improvement in physical function as measured by maximal oxygen uptake.


Condition Intervention
Kidney Failure, Chronic
Procedure: hemodialysis

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Primary Purpose: Treatment
Official Title: Comparison of Daily Nocturnal Hemodialysis With Daily Hemodialysis

Resource links provided by NLM:


Further study details as provided by National Center for Research Resources (NCRR):

  Eligibility

Ages Eligible for Study:   21 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Adult patients with chronic renal failure requiring intermittent hemodialysis with a life expectancy of greater than 2 years

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00012441

Locations
United States, Missouri
Washington University School of Medicine Recruiting
St. Louis, Missouri, United States, 63108
Contact: Brent W. Miller, M.D.    314-286-0801      
Principal Investigator: Brent W. Miller, M.D.         
Sponsors and Collaborators
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00012441     History of Changes
Other Study ID Numbers: NCRR-M01RR00036-0781
Study First Received: March 6, 2001
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Keywords provided by National Center for Research Resources (NCRR):
Renal Dialysis

Additional relevant MeSH terms:
Kidney Failure, Chronic
Renal Insufficiency
Renal Insufficiency, Chronic
Kidney Diseases
Urologic Diseases

ClinicalTrials.gov processed this record on April 16, 2014