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Protection Against Benzene Toxicity

This study has been completed.
Sponsor:
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:
NCT00011453
First received: February 21, 2001
Last updated: June 23, 2005
Last verified: July 2002
History of Changes
  Purpose

We are investigating the role of an enzyme (NQO1) in protection against the bone marrow toxicity of the occupational and environmental toxicant benzene. All of the proposed studies involve use of human bone marrow cells in-vitro to define mechanisms of NQO1-mediated protection. Cells are obtained from healthy volunteers and protocols have undergone IRB review and approval.


Condition
Leukemia
Aplastic Anemia

Study Type: Observational
Study Design: Additional Descriptors: Convenience Sample
Primary Purpose: Screening
Time Perspective: Prospective
Official Title: NQO1 in Protection Against Benzene Toxicity

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Study Start Date: July 1998
Estimated Study Completion Date: June 2001
  Eligibility

Ages Eligible for Study:   21 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Healthy adult volunteers with blood counts in normal ranges and without evidence of hepatitis or HIV infection.

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00011453

Locations
United States, Colorado
University of Colorado Health Sciences Center
Denver, Colorado, United States, 80262
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00011453     History of Changes
Other Study ID Numbers: 9554-CP-001
Study First Received: February 21, 2001
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
NQO1
DT-diaphorase
Benzene
Leukemia
Aplastic anemia

Additional relevant MeSH terms:
Anemia
Anemia, Aplastic
Leukemia
Hematologic Diseases
 Bone Marrow Diseases
Neoplasms by Histologic Type
Neoplasms

ClinicalTrials.gov processed this record on May 22, 2013