Protection Against Benzene Toxicity

This study has been completed.

First Received on February 21, 2001. Last Updated on June 23, 2005 History of Changes

Sponsor:	National Institute of Environmental Health Sciences (NIEHS)
Information provided by:	National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:	NCT00011453

Purpose

We are investigating the role of an enzyme (NQO1) in protection against the bone marrow toxicity of the occupational and environmental toxicant benzene. All of the proposed studies involve use of human bone marrow cells in-vitro to define mechanisms of NQO1-mediated protection. Cells are obtained from healthy volunteers and protocols have undergone IRB review and approval.

Condition
Leukemia Aplastic Anemia

Study Type:	Observational
Study Design:	Additional Descriptors: Convenience Sample Primary Purpose: Screening Time Perspective: Prospective
Official Title:	NQO1 in Protection Against Benzene Toxicity

Resource links provided by NLM:

MedlinePlus related topics: Anemia Aplastic Anemia Leukemia

U.S. FDA Resources

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Study Start Date:	July 1998
Estimated Study Completion Date:	June 2001

Eligibility

Ages Eligible for Study:	21 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Healthy adult volunteers with blood counts in normal ranges and without evidence of hepatitis or HIV infection.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00011453

Locations

United States, Colorado
University of Colorado Health Sciences Center
Denver, Colorado, United States, 80262

Sponsors and Collaborators

National Institute of Environmental Health Sciences (NIEHS)

More Information

No publications provided

ClinicalTrials.gov Identifier:	NCT00011453 History of Changes
Other Study ID Numbers:	9554-CP-001
Study First Received:	February 21, 2001
Last Updated:	June 23, 2005
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):

NQO1
DT-diaphorase
Benzene
Leukemia
Aplastic anemia

Additional relevant MeSH terms:

Anemia
Anemia, Aplastic
Leukemia
Hematologic Diseases

Bone Marrow Diseases
Neoplasms by Histologic Type
Neoplasms

ClinicalTrials.gov processed this record on February 09, 2012