Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency

This study has been completed.
Sponsor:
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
NCT00011141
First received: February 12, 2001
Last updated: June 23, 2005
Last verified: December 2003
  Purpose

The etiology of immune-mediated diabetes mellitus (IMD) remains unclear. However, previous studies indicate that autoimmunity may be a result of dysfunction of natural killer T cells (NK-T cells). Newly diagnoses patients with IMD have been shown in our laboratory to have significantly lower NK-T cells than normal controls. Other studies have shown that oral administration of lactobacillus can boost NK-T cell activity in children with HIV without side effects. Our objective is to evaluate the effect of lactobacillus administration on NK-T cell activity in patients with IMD


Condition Intervention
Diabetes Mellitus
Drug: Oral lactobacillus administration

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency

Resource links provided by NLM:


Further study details as provided by National Center for Research Resources (NCRR):

  Eligibility

Ages Eligible for Study:   1 Year to 95 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Recently diagnosed (within the last 6 months) patients with immune-mediated (type 1) diabetes

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00011141

Locations
United States, New York
Cornell University
New York, New York, United States, 10021
Sponsors and Collaborators
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00011141     History of Changes
Other Study ID Numbers: NCRR-M01RR06020-0165
Study First Received: February 12, 2001
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Keywords provided by National Center for Research Resources (NCRR):
Immune-mediated diabetes mellitus

Additional relevant MeSH terms:
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases

ClinicalTrials.gov processed this record on April 22, 2014