Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks

This study has been completed.
Sponsor:
Information provided by:
National Center for Complementary and Alternative Medicine (NCCAM)
ClinicalTrials.gov Identifier:
NCT00010530
First received: February 2, 2001
Last updated: December 4, 2009
Last verified: December 2009
  Purpose

The purpose of this study is to evaluate the effects of meditation on older African Americans with documented cardiovascular disease (CVD).


Condition Intervention Phase
Cardiovascular Diseases
Procedure: Meditation
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Masking: Single Blind
Primary Purpose: Treatment
Official Title: Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks

Further study details as provided by National Center for Complementary and Alternative Medicine (NCCAM):

Study Start Date: September 1999
Study Completion Date: July 2006
Primary Completion Date: July 2006 (Final data collection date for primary outcome measure)
Detailed Description:

Cardiovascular disease (CVD) is the leading cause of death and disability in older African Americans, and accounts for 40% of the disproportionate risk for mortality observed in African Americans compared to white Americans. The majority of CVD patients experience acute cardiac events, many sudden and unexpected, despite conventional treatment of their disease and associated traditional risk factors. The pathophysiologic basis of these cardiac events is not fully established, but substantial evidence indicates that psychosocial stress and the sympathetic nervous system have adverse effects on both vasomotor function and long-term autonomic balance. Recent advances in the understanding of the pathophysiology of acute cardiac events-specifically, the roles that arterial vasomotor dysfunction and sympathetic nervous system imbalance play in the pathophysiology of such acute events-provide a platform for a new mechanistic investigation of the interplay of psychosocial and environmental stress and CVD. Preliminary evidence demonstrating elevated peripheral vasoconstriction due to stress-mediated sympathetic nervous system response in African Americans further suggests that these mechanisms are particularly relevant in this group.

  Eligibility

Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • African-American (self-identified)
  • Local residence
  • Able to participate
  • Coronary artery disease by MI, CABG, PTCA (>3 months prior), or angiography
  • Consent and referring MD approval
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00010530

Locations
United States, California
Charles R. Drew University of Medicine and Science
Los Angeles, California, United States
United States, Iowa
Maharishi University of Management Center for Health and Aging Studies
Fairfield, Iowa, United States, 52557
Sponsors and Collaborators
Investigators
Principal Investigator: Robert H. Schneider, MD Center for Health and Aging Studies
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00010530     History of Changes
Obsolete Identifiers: NCT00009087
Other Study ID Numbers: P50 AT000082-01P1, P50AT000082-01, P50AT000082-02
Study First Received: February 2, 2001
Last Updated: December 4, 2009
Health Authority: United States: Federal Government

Keywords provided by National Center for Complementary and Alternative Medicine (NCCAM):
CVD

Additional relevant MeSH terms:
Cardiovascular Diseases

ClinicalTrials.gov processed this record on April 17, 2014