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Dynamic Aspects of Amino Acid Metabolism

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2003 by National Center for Research Resources (NCRR).
Recruitment status was  Recruiting
Information provided by:
National Center for Research Resources (NCRR) Identifier:
First received: June 1, 2000
Last updated: June 23, 2005
Last verified: December 2003

This protocol seeks to define aspects of intestinal and hepatic uptake and metabolism of several amino acids. The major hypothesis to be tested is that the splanchic bed (intestine and liver) conserves essential amino acids and metabolites while synthesizing and metabolizing nonessential amino acids. The aims of the study include defining the relative roles of enteral and hepatic extraction/metabolism in the disposition of glutamate, alanine, methionine and other amino acids. Emphasis will also be placed on studies of the transamination of alpha-ketoisocaproic acid (KIC) to leucine since this reaction is of potential importance in the design of nutritional regimens for patients with renal disease.

Kidney Diseases

Study Type: Observational
Study Design: Observational Model: Natural History
Time Perspective: Cross-Sectional

Resource links provided by NLM:

Further study details as provided by National Center for Research Resources (NCRR):


Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • normal weight-for-height weight 50-80 kg
  • normal physical activity
  • no significant medical history
  • healthy by medical exam and lab blood testing

Exclusion Criteria:

  • subjects who exercise vigorously
  • subjects who smoke
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00005767

Contact: Dwight Matthews, Ph.D. 1-802-646-8114

United States, Vermont
University of Vermont Recruiting
Burlington, Vermont, United States, 05401
Contact: Dwight Matthews, Ph.D.    802-646-8114      
Sponsors and Collaborators
  More Information

No publications provided Identifier: NCT00005767     History of Changes
Other Study ID Numbers: NCRR-M01RR00109-0740, M01RR00109
Study First Received: June 1, 2000
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Keywords provided by National Center for Research Resources (NCRR):
Amino Acid Metabolism

Additional relevant MeSH terms:
Kidney Diseases
Urologic Diseases processed this record on November 20, 2014