Blood Factors and Diabetic Retinopathy
This study will determine whether certain factors in the blood are associated with the severity of diabetic retinopathy.
Patients age 10 years and older with diabetes mellitus and diabetic retinopathy may be eligible for this study. Those enrolled will represent a range of diabetic retinopathy from minimal to severe. Participants will undergo the following procedures:
- medical history
- thorough eye examination
- photographs of the eye
- blood tests to measure blood lipids (cholesterol and triglycerides) and serum creatinine (for kidney function)
- blood tests to measure levels of blood factors (cell adhesion molecules, chemokines and vascular endothelial growth factor) that may be related to the progression of diabetic retinopathy
- blood pressure measurement
This study may lead to a better understanding of how diabetic retinopathy develops and progresses.
|Official Title:||Study of Association of Serum Factors With Diabetic Retinopathy|
|Study Start Date:||May 2000|
|Estimated Study Completion Date:||December 2010|
Participants with a range of severity of diabetic retinopathy and healthy volunteers will be evaluated once for serum levels of cell adhesion molecules, chemokines and vascular endothelial growth factor. This study may lead to a better understanding of the pathogenesis of diabetic retinopathy and the identifying of possible targets for treatment. All study participants will undergo an ocular exam and ophthalmic photography. Blood is drawn for the analysis of these serum factors.
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|