Community Based Study on Occupational Asthma - Full Text View

Purpose

To examine the occupations, industries and exposures in the work-place which were associated with a high risk for asthma and other adverse respiratory health effects, with particular emphasis on specific exposures of predominantly female occupations (irritants, detergents and other asthmagens), and of other high risk major occupations which had not been adequately examined.

Condition
Asthma Lung Diseases

Study Type:	Observational
Study Design:	Observational Model: Natural History Time Perspective: Longitudinal

Resource links provided by NLM:

MedlinePlus related topics: Asthma

U.S. FDA Resources

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date:	May 1999
Estimated Study Completion Date:	April 2003

Detailed Description:

BACKGROUND:

Respiratory diseases are strongly related with exposure in the workplace. A considerable proportion of adult onset asthma is associated with these exposures. The importance of occupational risk factors for asthma has been underestimated, particularly among women. The occupational asthma study (ECRHS-OA) forms part of a wider international multicentre survey on respiratory health (European Community Respiratory Health Survey-ECRHS). The first phase of the ECRHS was conducted in 1991/92 and examined risk factors for asthma and atopy in subjects aged 20-44 years. The study updated (ECRHS-II), following-up approximately 17,000 young adults from 12 countries (Australia, Belgium, France, Germany, Iceland, Italy, Norway, Spain, Sweden, Switzerland, UK and USA).

The study provided valid and precise estimates on the importance of specific occupations, industries and exposures in relation to asthma incidence and prevalence, similar estimates for other respiratory symptoms and diseases and also for declines in pulmonary function.

DESIGN NARRATIVE:

Longitudinal, community-based, multicenter study. Those subjects who took part in the first occupational asthma study survey were re-contacted in 1999, to determine risk factors for incidence and remission of asthma, other respiratory symptoms, atopy, changes in bronchial responsiveness and lung function. Subjects were asked to perform a forced spirometry, methacholine challenge and to provide blood samples for IgE testing. A questionnaire administrated by trained interviewers was delivered requesting information on respiratory symptoms and diseases, socio-demographic factors, tobacco smoking, complete occupational history since the last survey, environmental exposures, family history, diet, treatment and use of health services. Modular occupational questionnaires were developed for subjects employed as cleaners, homemakers, welders, metal workers, nurses, and subjects exposed to organic dusts in the paper and textile industries.

Eligibility

Ages Eligible for Study:	20 Years to 44 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

No eligibility criteria

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00005755

Sponsors and Collaborators

National Heart, Lung, and Blood Institute (NHLBI)

Investigators

Investigator:

Manolis Kogevinas

Municipal Institute of Medical Research

More Information

Publications:

Zock JP, Kogevinas M, Sunyer J, Almar E, Muniozguren N, Payo F, Sanchez JL, Anto JM. Asthma risk, cleaning activities and use of specific cleaning products among Spanish indoor cleaners. Scand J Work Environ Health. 2001 Feb;27(1):76-81.

Zock JP, Kogevinas M, Sunyer J, Jarvis D, Toren K, Anto JM. Asthma characteristics in cleaning workers, workers in other risk jobs and office workers. Eur Respir J. 2002 Sep;20(3):679-85.

Zock JP, Cavalle N, Kromhout H, Kennedy SM, Sunyer J, Jaen A, Muniozguren N, Payo F, Almar E, Sanchez JL, Anto JM, Kogevinas M. Evaluation of specific occupational asthma risks in a community-based study with special reference to single and multiple exposures. J Expo Anal Environ Epidemiol. 2004 Sep;14(5):397-403.

de Vocht F, Zock JP, Kromhout H, Sunyer J, Anto JM, Burney P, Kogevinas M. Comparison of self-reported occupational exposure with a job exposure matrix in an international community-based study on asthma. Am J Ind Med. 2005 May;47(5):434-42.

ClinicalTrials.gov Identifier:	NCT00005755 History of Changes
Other Study ID Numbers:	5109
Study First Received:	May 25, 2000
Last Updated:	January 27, 2006
Health Authority:	United States: Federal Government

Additional relevant MeSH terms:

Asthma
Lung Diseases
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive

Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases

ClinicalTrials.gov processed this record on May 23, 2013