Hemochromatosis and Iron Overload Screening Study (HEIRS)

This study has been completed.

Sponsor:

Information provided by:

National Heart, Lung, and Blood Institute (NHLBI)

ClinicalTrials.gov Identifier:

NCT00005541

First received: May 25, 2000

Last updated: April 13, 2009

Last verified: April 2009

History of Changes

Purpose

To determine the prevalence, genetic and environmental determinants, and potential clinical, personal, and societal impact of iron overload and hereditary hemochromatosis, in a multi-center, multiethnic, primary care-based sample of 100,000 adults. The study is conducted by the Division of Epidemiology and Clinical Applications of the NHLBI, the Division of Blood Diseases and Resources of the NHLBI, and the Ethical, Legal, and Social Implications (ELSI) Research Program of the NHGRI.

Condition
Blood Disease Hemochromatosis Iron Overload

Study Type:

Observational

Resource links provided by NLM:

Genetics Home Reference related topics: hemochromatosis

MedlinePlus related topics: Blood Disorders Hemochromatosis Iron

U.S. FDA Resources

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date:	January 2000
Study Completion Date:	January 2006
Primary Completion Date:	January 2006 (Final data collection date for primary outcome measure)

Show Detailed Description

Eligibility

Ages Eligible for Study:	25 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

No eligibility criteria

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00005541

Sponsors and Collaborators

National Heart, Lung, and Blood Institute (NHLBI)

Investigators

Investigator:	Ronald Acton	University of Alabama at Birmingham
Investigator:	Paul Adams	London Health Sciences Centre
Investigator:	John Eckfeldt	University of Minnesota - Clinical and Translational Science Institute
Investigator:	Victor Gordeuk	Howard University
Investigator:	Emily Harris	Kaiser Foundation Research Institute
Investigator:	Christine McLaren	University of California
Investigator:	David Reboussin	Wake Forest University

More Information

Publications:

McLaren CE, Barton JC, Adams PC, Harris EL, Acton RT, Press N, Reboussin DM, McLaren GD, Sholinsky P, Walker AP, Gordeuk VR, Leiendecker-Foster C, Dawkins FW, Eckfeldt JH, Mellen BG, Speechley M, Thomson E. Hemochromatosis and Iron Overload Screening (HEIRS) Study Design for an Evaluation of 100,000 Primary Care-Based Adults. Am J Med Sci. 2003 Feb;325(2):53-62.

Adams PC, Reboussin DM, Leiendecker-Foster C, Moses GC, McLaren GD, McLaren CE, Dawkins FW, Kasvosve I, Acton RT, Barton JC, Zaccaro D, Harris EL, Press R, Chang H, Eckfeldt JH. Comparison of the Unsaturated Iron-Binding Capacity with Transferrin Saturation as a Screening Test to Detect C282Y Homozygotes for Hemochromatosis in 101 168 Participants in the Hemochromatosis and Iron Overload Screening (HEIRS) Study. Clin Chem. 2005 Apr 15; [Epub ahead of print] No abstract available.

Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, Gordeuk VR, Leiendecker-Foster C, Speechley M, Snively BM, Holup JL, Thomson E, Sholinsky P; Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med. 2005 Apr 28;352(17):1769-78.

ClinicalTrials.gov Identifier:	NCT00005541 History of Changes
Other Study ID Numbers:	5083
Study First Received:	May 25, 2000
Last Updated:	April 13, 2009
Health Authority:	United States: Federal Government

Additional relevant MeSH terms:

Hematologic Diseases
Hemochromatosis
Iron Overload
Metal Metabolism, Inborn Errors

Metabolism, Inborn Errors
Genetic Diseases, Inborn
Iron Metabolism Disorders
Metabolic Diseases

ClinicalTrials.gov processed this record on June 13, 2013

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