Salt Sensitivity, Cardiovascular and Metabolic Disease

This study has been completed.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI) Identifier:
First received: May 25, 2000
Last updated: June 23, 2005
Last verified: March 2004

To identify the role of salt-sensitivity of blood pressure in the pathogenesis of hypertension.

Cardiovascular Diseases
Heart Diseases
Angina Pectoris
Cerebrovascular Accident
Myocardial Infarction
Diabetes Mellitus
Heart Failure, Congestive
Heart Failure

Study Type: Observational
Study Design: Observational Model: Natural History

Resource links provided by NLM:

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: January 1998
Estimated Study Completion Date: December 2001
Detailed Description:


Approximately 498 of 750 normal and hypertensive subjects who were carefully characterized in terms of blood pressure response to salt loading and depletion in the late 1970s were re-examined to identify physiological factors contributing to salt-sensitivity of blood pressure. This helped to confirm preliminary observations suggesting that salt sensitivity in normotensive subjects predicted the subsequent development of hypertension with aging. In addition, longitudinal observations in hypertensive patients and in normotensives helped to determine whether salt-sensitivity or salt-resistance of blood pressure were associated with differences in the risk for development of specific forms of cardiovascular disease (stroke, angina, myocardial infarction, congestive heart failure), renal and metabolic (diabetes mellitus) disorders.


Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No

No eligibility criteria

  Contacts and Locations
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Please refer to this study by its identifier: NCT00005489

Sponsors and Collaborators
Investigator: Myron Weinberger Indiana University-Purdue University
  More Information

Publications: Identifier: NCT00005489     History of Changes
Other Study ID Numbers: 5005
Study First Received: May 25, 2000
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Angina Pectoris
Cardiovascular Diseases
Cerebral Infarction
Diabetes Mellitus
Heart Diseases
Heart Failure
Myocardial Infarction
Brain Diseases
Brain Infarction
Brain Ischemia
Central Nervous System Diseases
Cerebrovascular Disorders
Chest Pain
Endocrine System Diseases
Glucose Metabolism Disorders
Metabolic Diseases
Myocardial Ischemia
Nervous System Diseases
Pathologic Processes
Signs and Symptoms
Vascular Diseases processed this record on October 29, 2014