Epidemiology of Persistent Pulmonary Hypertension of the Newborn - SCOR in Lung Biology and Diseases in Infants and Children

This study has been completed.

Sponsor:

Information provided by:

National Heart, Lung, and Blood Institute (NHLBI)

ClinicalTrials.gov Identifier:

NCT00005323

First received: May 25, 2000

Last updated: June 23, 2005

Last verified: October 2001

History of Changes

Purpose

To conduct an epidemiologic study of persistent pulmonary hypertension of the newborn ( PPHN) infant.

Condition
Lung Diseases Cardiovascular Diseases Defect, Congenital Heart Heart Diseases Persistent Fetal Circulation Syndrome

Study Type:	Observational
Study Design:	Observational Model: Natural History

Resource links provided by NLM:

MedlinePlus related topics: Heart Diseases High Blood Pressure Pulmonary Hypertension

U.S. FDA Resources

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date:	December 1991
Estimated Study Completion Date:	November 1996

Detailed Description:

BACKGROUND:

The study on the epidemiology of persistent pulmonary hypertension of the newborn (PPHN) was a subproject within a Specialized Center of Research (SCOR) in Lung Biology and Diseases in Infants and Children. The SCOR and its subproject were awarded in December, 1991. Dollars were estimated at 20 percent of total center dollars.

DESIGN NARRATIVE:

Data from a previous study of PPHN were analyzed. The objectives were to: identify the effects of a variety of potentially adverse prenatal exposures from interview data; formulate multi-variate models of risk of PPHN to determine if smoking or use of prostaglandin inhibitors increased the risk of PPHN; explore associations of PPHN with history of illicit drug use and maternal hypoxia; examine the relationships of postnatal care and perinatal risk factors on the incidence and outcome of PPHN; test the relationships of PPHN to the biochemical presence of nicotine and drugs in neonatal urine.

Eligibility

Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	No

Criteria

No eligibility criteria

Contacts and Locations

No Contacts or Locations Provided

More Information

Publications:

Derkach IuS, Osherovich AM, Miasnenko AM. [Organization of the equipment and public health measures in virological laboratories of epidemiological health stations] Lab Delo. 1984;(6):374-7. Russian. No abstract available.

Christou H, Adatia I, Van Marter LJ, Kane JW, Thompson JE, Stark AR, Wessel DL, Kourembanas S. Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5'-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension. J Pediatr. 1997 Apr;130(4):603-11.

ClinicalTrials.gov Identifier:	NCT00005323 History of Changes
Other Study ID Numbers:	4104
Study First Received:	May 25, 2000
Last Updated:	June 23, 2005
Health Authority:	United States: Federal Government

Additional relevant MeSH terms:

Congenital Abnormalities
Cardiovascular Diseases
Heart Defects, Congenital
Heart Diseases
Hypertension, Pulmonary

Lung Diseases
Persistent Fetal Circulation Syndrome
Cardiovascular Abnormalities
Respiratory Tract Diseases
Infant, Newborn, Diseases

ClinicalTrials.gov processed this record on May 16, 2013

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