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Adiposity and Fat Patterning in Black Americans

This study has been completed.
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00005248
First received: May 25, 2000
Last updated: June 23, 2005
Last verified: May 2002
  Purpose

To examine the relationships of obesity and fat patterning with morbidity and mortality in Black Americans.


Condition
Heart Diseases
Diabetes Mellitus
Obesity

Study Type: Observational

Resource links provided by NLM:


Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: August 1989
Estimated Study Completion Date: July 1992
Detailed Description:

BACKGROUND:

Studies have shown that fat patterning is an important risk factor for diabetes and possibly cardiovascular diseases. The Secretary's Task Force on Black and Minority Health in 1985 concluded that diabetes and cardiovascular diseases were among the six causes of death that contribute most to the disparity in death rates between Blacks and whites, yet the relationship of fat patterning with these diseases was largely unstudied in Blacks. Since there are known racial differences in growth rates, body proportions, and adiposity, it cannot be assumed that studies done on whites are applicable to Blacks.

The Charleston Heart Study began in 1960 with the examination of a random sample of 2181 residents of Charleston County. Approximately one-third of the sample was Black. The cohort was re-examined in 1963-1964, 1974-1975, and 1984-1985, and the fifth recall involving physical examination, electrocardiogram, echocardiograph, plasma glucose and lipid assays, physical disability assessment, and 24-hour Holter monitoring was completed. In the 1963-1964 recall, 102 high socioeconomic status Black men were added to the cohort. Also, in the 1963-1964 recall a battery of anthropometric measurements were taken on about half the cohort and these measurements and others were included in the 1987-1988 recall. Thus height, weight, reported weight at age 25, circumference of the chest at inhale and exhale, circumference at the umbilicus and mid-arm circumference were available on the same individuals from the 1963-1964 and the 1987-1988 examinations. In addition, skinfolds at the triceps, biceps, subscapular, suprailiac and lower thigh and circumference at the hips were measured in the latter recall. The fifth examination was completed in 1989 under separate NHLBI grant support.

DESIGN NARRATIVE:

Cross-sectional relationships were estimated between anthropometric measures of body dimensions such as abdominal, central and upper body fat patterning, and total adiposity and the dependent variables of diabetes, blood pressure, plasma lipids and glucose, and left ventricular wall thickness. Anthropometric predictors of diabetes, blood pressure, plasma lipids and glucose, and left ventricular wall thickness were identified over a 24 year interval. Anthropometric predictors of survival were identified over a 25 year period with reference to mortality for coronary heart disease, cardiovascular disease, and all-cause mortality. Body dimensions were described by race and sex groups and changes in the shapes of individuals over a 24 year interval were examined. The importance of changes in anthropometric measurements with aging was determined for the prediction of diabetes, blood pressure, plasma lipids and glucose, left ventricular wall thickness, mortality from all causes and from coronary heart disease and cardiovascular disease.

  Eligibility

Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

No eligibility criteria

  Contacts and Locations
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No Contacts or Locations Provided
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00005248     History of Changes
Other Study ID Numbers: 1130
Study First Received: May 25, 2000
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Diabetes Mellitus
Heart Diseases
Cardiovascular Diseases
Endocrine System Diseases
Glucose Metabolism Disorders
Metabolic Diseases

ClinicalTrials.gov processed this record on November 20, 2014