Survival After Myocardial Infarction in A Biethnic Texas Community (Corpus Christi Heart Project)

This study has been completed.
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00005198
First received: May 25, 2000
Last updated: June 23, 2005
Last verified: August 2001
  Purpose

To determine the natural history of coronary heart disease in the biethnic community of Corpus Christi, Texas.


Condition
Cardiovascular Diseases
Hypertension
Coronary Disease
Myocardial Infarction

Study Type: Observational

Resource links provided by NLM:


Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: April 1987
Estimated Study Completion Date: March 1998
Detailed Description:

BACKGROUND:

The decline in coronary heart disease mortality in the United States may be due to decreasing incidence of clinically apparent coronary heart disease or increasing survival from its first clinical appearance or both. Prior to 1987, few data were available to confirm either one directly. However, increased risk, decreased medical care, or both may predispose the Mexican-American population to increased recurrence of myocardial infarction and decreased post myocardial infarction survival, and an overall greater mortality among survivors of myocardial infarction, than are observed for Anglos in the same community setting. The significance of the potential results lies most importantly in the following aspects of this research: estimation of the community-based incidence of hospitalization for suspect, definite or possible myocardial infarction; precise determination of recurrence rates and survival curves after myocardial infarction in community-wide hospital-based cohorts; analysis of the relation of the above to risk status as ascertained at hospitalization and to health care and preventive practices assessed periodically post-myocardial infarction; and comparison of these observations between Anglos and Mexican-Americans, a group of special interest and concern because of expected differences in natural history of coronary heart disease and near total lack of the relevant data.

DESIGN NARRATIVE:

Patients hospitalized for acute coronary heart disease (CHD) in seven acute care hospitals in Nueces County, Texas were identified by active concurrent case registration. Baseline data on clinical, prognostic and sociodemographic characteristics of these patients at the time of the event were collected from the medical record and by interview with the patient. Patients with events meeting diagnostic criteria for acute myocardial infarction (MI) were followed directly through contacts at three months post-discharge and at the anniversary of discharge thereafter to ascertain vital status and to collect information about recurrent myocardial infarction, other changes in health status, and health care practices in the interim. Endpoints included all-cause mortality and deaths attributed to coronary heart disease, and fatal and non-fatal myocardial infarction. Data analysis included examination of survival and recurrence of myocardial infarction for the entire cohort of myocardial infarction patients and within ethnic groups; evaluation of potential prognostic factors within and between ethnic groups; and comparison of survival and myocardial infarction recurrence between ethnic groups after adjustment for both baseline and time-dependent covariates.

The study was renewed in 1992 to continue to identify hospitalized MI and CHD mortality as well as angioplasty, and bypass surgery among Mexican-Americans and non-Hispanic Whites. The investigators calculated incidence rates for hospitalized MI, for the use of cardiac revascularization, and rates for post-MI mortality, and for both all cause and CHD mortality in the community. They also described trends in these aspects of CHD over an eight year period and determined if ethnic differences existed.

  Eligibility

Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

No eligibility criteria

  Contacts and Locations
No Contacts or Locations Provided
  More Information

Publications:
Labarthe DR: Changing Patterns in the Epidemiology of Coronary Artery Disease: Trends in Survival After Myocardial Infarction. In: Long-Term Management of Patients After Myocardial Infarction. Kappagoda CT, Greenwood PV, (Eds), Pages 17-30, 1987
Slater CH, Carlton B, Ramirez G, Ashton C: Heart Disease, Strategies for Prevention. Eval Health Prof, 10(3):255-286, 1987

ClinicalTrials.gov Identifier: NCT00005198     History of Changes
Other Study ID Numbers: 1077
Study First Received: May 25, 2000
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Cardiovascular Diseases
Coronary Disease
Coronary Artery Disease
Hypertension
Infarction
Myocardial Infarction
Myocardial Ischemia
Heart Diseases
Vascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Ischemia
Pathologic Processes
Necrosis

ClinicalTrials.gov processed this record on April 21, 2014