Sodium Transport: Genetics and Hypertension - Full Text View

Purpose

Originally, to determine whether genetic alterations in pathways of sodium ion transport in the red blood cells of children could predict their risk of developing primary hypertension in adulthood. In 1992, the objective was to determine the genetic basis of interindividual variation in the risk of essential hypertension in the population at large using the Rochester Family Heart Study.

Condition
Cardiovascular Diseases Heart Diseases Hypertension

Study Type:	Observational
Study Design:	Observational Model: Natural History

Resource links provided by NLM:

MedlinePlus related topics: Heart Diseases High Blood Pressure

U.S. FDA Resources

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date:	April 1984
Estimated Study Completion Date:	March 1996

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Eligibility

Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	No

Criteria

No eligibility criteria

Contacts and Locations

No Contacts or Locations Provided

More Information

Publications:

Boerwinkle E, Turner ST, Sing CF. The role of the genetics of sodium lithium countertransport in the determination of blood pressure variability in the population at large. Prog Clin Biol Res. 1984;165:479-507. No abstract available.

Sing CF, Boerwinkle E: The Genetics of Blood Pressure Variability: An Overview. In: Proceedings, Children's Blood Pressure: The Eighty-Eighth Ross Conference on Pediatric Research. Ross Laboratories, 1984

Turner ST, Fairbanks VF. Is measurement of erythrocyte Na+ influx useful for ascertainment of essential hypertension? Mayo Clin Proc. 1984 Jul;59(7):506-8. No abstract available.

Turner ST, Johnson M, Boerwinkle E, Richelson E, Taswell HF, Sing CF. Sodium-lithium countertransport and blood pressure in healthy blood donors. Hypertension. 1985 Nov-Dec;7(6 Pt 1):955-62.

Boerwinkle E, Chakraborty R, Sing CF. The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods. Ann Hum Genet. 1986 May;50 ( Pt 2):181-94.

Sing CF, Boerwinkle E, Turner ST. Genetics of primary hypertension. Clin Exp Hypertens A. 1986;8(4-5):623-51. Review.

Richelson E, Snyder K, Carlson J, Johnson M, Turner S, Lumry A, Boerwinkle E, Sing CF. Lithium ion transport by erythrocytes of randomly selected blood donors and manic-depressive patients: lack of association with affective illness. Am J Psychiatry. 1986 Apr;143(4):457-62.

Boerwinkle E, Turner ST, Weinshilboum R, Johnson M, Richelson E, Sing CF. Analysis of the distribution of erythrocyte sodium lithium countertransport in a sample representative of the general population. Genet Epidemiol. 1986;3(5):365-78.

Turner ST, Boerwinkle E, Johnson M, Richelson E, Sing CF. Sodium-lithium countertransport in ambulatory hypertensive and normotensive patients. Hypertension. 1987 Jan;9(1):24-34.

Turner ST, Weidman WH, Michels VV, Reed TJ, Ormson CL, Fuller T, Sing CF. Distribution of sodium-lithium countertransport and blood pressure in Caucasians five to eighty-nine years of age. Hypertension. 1989 Apr;13(4):378-91.

Rebbeck TR, Turner ST, Michels VV, Moll PP. Genetic and environmental explanations for the distribution of sodium-lithium countertransport in pedigrees from Rochester, MN. Am J Hum Genet. 1991 Jun;48(6):1092-104.

Sing CF, Haviland MB, Templeton AR, Zerba KE, Reilly SL. Biological complexity and strategies for finding DNA variations responsible for inter-individual variation in risk of a common chronic disease, coronary artery disease. Ann Med. 1992 Dec;24(6):539-47. Review.

Reilly SL, Ferrell RE, Kottke BA, Sing CF. The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, Minnesota. II. Regression relationships with concomitants. Am J Hum Genet. 1992 Dec;51(6):1311-24.

Turner ST, Rebbeck TR, Sing CF. Sodium-lithium countertransport and probability of hypertension in Caucasians 47 to 89 years old. Hypertension. 1992 Dec;20(6):841-50.

Schwartz GL, Turner ST, Sing CF. Twenty-four-hour blood pressure profiles in normotensive sons of hypertensive parents. Hypertension. 1992 Dec;20(6):834-40.

Mailly F, Moll P, Kottke BA, Kamboh MI, Humphries SE, Ferrell RE. Estimation of the frequency of isoform-genotype discrepancies at the apolipoprotein E locus in heterozygotes for the isoforms. Genet Epidemiol. 1992;9(4):239-48.

Reilly SL, Ferrell RE, Kottke BA, Kamboh MI, Sing CF. The gender-specific apolipoprotein E genotype influence on the distribution of lipids and apolipoproteins in the population of Rochester, MN. I. Pleiotropic effects on means and variances. Am J Hum Genet. 1991 Dec;49(6):1155-66. Erratum in: Am J Hum Genet 1992 Oct;51(4):942.

Kottke BA, Moll PP, Michels VV, Weidman WH. Levels of lipids, lipoproteins, and apolipoproteins in a defined population. Mayo Clin Proc. 1991 Dec;66(12):1198-208.

Kaprio J, Ferrell RE, Kottke BA, Kamboh MI, Sing CF. Effects of polymorphisms in apolipoproteins E, A-IV, and H on quantitative traits related to risk for cardiovascular disease. Arterioscler Thromb. 1991 Sep-Oct;11(5):1330-48.

Turner ST, Michels VV. Sodium-lithium countertransport and hypertension in Rochester, Minnesota. Hypertension. 1991 Aug;18(2):183-90.

Pérusse L, Moll PP, Sing CF. Evidence that a single gene with gender- and age-dependent effects influences systolic blood pressure determination in a population-based sample. Am J Hum Genet. 1991 Jul;49(1):94-105.

Sing CF, Moll PP. Genetics of atherosclerosis. Annu Rev Genet. 1990;24:171-87. Review. No abstract available.

Reilly SL, Kottke BA, Sing CF. The effects of generation and gender on the joint distributions of lipid and apolipoprotein phenotypes in the population at large. J Clin Epidemiol. 1990;43(9):921-40.

Kwon JM, Boehnke M, Burns TL, Moll PP. Commingling and segregation analyses: comparison of results from a simulation study of a quantitative trait. Genet Epidemiol. 1990;7(1):57-68.

Zerba KE, Friedlaender JS, Sing CF. Heterogeneity of the blood pressure distribution among Solomon Islands societies with increasing acculturation. Am J Phys Anthropol. 1990 Apr;81(4):493-511.

Rebbeck TR, Turner ST, Sing CF. Sodium-lithium countertransport genotype and the probability of hypertension in adults. Hypertension. 1993 Oct;22(4):560-8.

Reilly SL, Sing CF, Savageau MA, Turner ST. Analysis of systems influencing renal hemodynamics and sodium excretion. I. Biochemical systems theory. Integr Physiol Behav Sci. 1994 Jan-Mar;29(1):55-73.

Turner ST, Reilly SL. Renal sodium excretion in sons of hypertensive parents. Hypertension. 1993 Sep;22(3):323-30.

Kardia SL, Sing CF, Turner ST. The response of renal plasma flow to angiotensin II infusion in a population-based sample and its association with the parental history of essential hypertension. J Hypertens. 1997 May;15(5):483-93.

Stengård JH, Zerba KE, Turner ST, Sing CF. A biometrical study of the relationship between sodium-lithium countertransport and triglycerides. Ann Hum Genet. 1997 Mar;61(Pt 2):121-36.

Turner ST, Sing CF. Erythrocyte sodium transport and the probability of having hypertension. J Hypertens. 1996 Jul;14(7):829-37.

Flickinger AL, Lerman LO, Sheedy PF 2nd, Turner ST. The relationship between renal cortical volume and predisposition to hypertension. Am J Hypertens. 1996 Aug;9(8):779-86.

Schwartz GL, Turner ST, Sing CF. Association of genetic variation with interindividual variation in ambulatory blood pressure. J Hypertens. 1996 Feb;14(2):251-8.

Rebbeck TR, Turner ST, Sing CF. Probability of having hypertension: effects of sex, history of hypertension in parents, and other risk factors. J Clin Epidemiol. 1996 Jul;49(7):727-34.

Flickinger AL, Burnett JC Jr, Turner ST. Atrial natriuretic peptide and blood pressure in a population-based sample. Mayo Clin Proc. 1995 Oct;70(10):932-8.

Turner ST, Reilly SL. Fallacy of indexing renal and systemic hemodynamic measurements for body surface area. Am J Physiol. 1995 Apr;268(4 Pt 2):R978-88.

ClinicalTrials.gov Identifier:	NCT00005166 History of Changes
Other Study ID Numbers:	1040
Study First Received:	May 25, 2000
Last Updated:	June 23, 2005
Health Authority:	United States: Federal Government

Additional relevant MeSH terms:

Cardiovascular Diseases
Heart Diseases
Hypertension
Vascular Diseases

ClinicalTrials.gov processed this record on May 23, 2013