Minneapolis Children's Blood Pressure Study

This study has been completed.
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00005141
First received: May 25, 2000
Last updated: June 23, 2005
Last verified: June 2000
  Purpose

To examine environmental and familial correlates of childhood blood pressure in order to predict elevated blood pressure in young adulthood. Also, to investigate the phenomena of tracking of blood pressure and obesity from childhood to young adulthood.


Condition
Cardiovascular Diseases
Heart Diseases
Hypertension
Obesity

Study Type: Observational

Resource links provided by NLM:


Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: September 1977
Estimated Study Completion Date: May 1997
Detailed Description:

BACKGROUND:

Hypertension has been clearly identified as a major risk factor for coronary heart disease and stroke. Hypertension screening and intervention programs for children are based on the concept that high normal blood pressure may be the childhood antecedent of adult hypertension or that blood pressure 'tracks' through childhood, adolescence, and adulthood. Blood pressure tracking has been well established for adults and young adults but results from various studies in children are controversial. At a Symposium on High Blood Pressure in the Young in 1979, it was concluded that there was insufficient information to recommend specific interventions for prepubertal children with blood pressure levels in the upper percentiles of the blood pressure distribution. Studies of longer duration with large population sizes and repeated blood pressure measurements over time were required to determine if blood pressure levels at these young ages were predictive of adult hypertension.

DESIGN NARRATIVE:

In the Spring of 1978 a total of 10,423 children, ages 6-8 were screened. A subsample was invited to join the study of blood pressure measurement. The sample was selected as follows: all children in the top five percent of the initial systolic blood pressure distribution; all children in the bottom five percent of the initial systolic blood pressure distribution; a random sample of one in two of the remaining Black children; a random sample of one in nine of the remaining white children; and all the remaining children of other races. Included were families of about 200 Native American children. Of 2,641 selected children, 878 refused leaving a sample of 1,753. Baseline data on age, race, sex, triceps skinfold thickness, dietary history, urinary sodium and potassium excretion, physiological measures, life event changes, medical history, demographic data and body size measurements of children and their parents were collected at the first home interview conducted between 1978 and 1979. The children were followed twice per year in 1978 to 1980 and 1982 to 1985 for blood pressure and body size. Annual measurements were made of blood pressure, height, weight, skinfold thickness, and body girths. Screenings continued through early 1991 when the cohort was 19-21 years of age.

Several substudies were conducted including the relationship of red blood cell cation transport to essential hypertension, Type A behavior assessments, and familial aggregation of coronary-prone behavior.

  Eligibility

Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

No eligibility criteria

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

Publications:
Prineas RJ, Gillum RF and Blackburn H: Possibilities for Primary Prevention of Hypertension. In: Childhood Prevention of Atherosclerosis and Hypertension, Lauer RM, Shekelle RB (Eds). Raven Press, New York, 1980
Prineas RJ, Gillum RF, Gomez-Marin O: The Determinants of Blood Pressure in Children: The Minneapolis Children's Blood Pressure Study. In: Loggie J, Horan M, Gruskin A, Hohn AR, Dunbar JB, Havlik RJ (Eds), NHLBI Workshop on Juvenile Hypertension, Bethesda, Maryland 1983. New York, Biomedical Information Corporation, 21-35, 1984
Prineas RJ, Gillum RF: U.S. Epidemiology of Hypertension in Blacks. In: Hall WD, Saunders E, Shulman NB (Eds). Hypertension in Blacks. New York Medical Publishers, Inc, Chicago, 17-36, 1985
Prineas RJ, Gomez-Marin O, Gillum RF: Children's Blood Pressure: Dietary Control of Blood Pressure by Weight Loss. In: Filer LJ Jr, Laujer RM (Eds). Children's Blood Pressure: Report of the Eighty-Eighth Ross Conference on Pediatric Research. Ross Laboratories, Columbus, Ohio, 120-129, 1985
Prineas R, Gomez-Marin O, Gillum R: Tracking of Blood Pressure in Children and Nonpharmacological Approaches to the Prevention of Hypertension. Ann Behav Med, 7(1):25-29, 1985
Luepker RV, Murray DM, Prineas RJ: Primary Prevention of Hypertension in Youth: A population Approach, In: Proceedings of the Fourth US-USSR Joint Symposium on Arterial Hypertension, Moscow, USSR. October-November 1984. Published 1986

ClinicalTrials.gov Identifier: NCT00005141     History of Changes
Other Study ID Numbers: 1012
Study First Received: May 25, 2000
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Hypertension
Cardiovascular Diseases
Heart Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on September 18, 2014