Long-Term Study of Cerebral Glucose Metabolism in Huntington's Disease
OBJECTIVES: I. Correlate clinical outcome with cerebral glucose metabolism in patients with Huntington's disease (HD) and their at-risk relatives.
II. Evaluate the efficacy of cerebral glucose metabolism in observing the pathophysiologic development of HD, monitoring responses to experimental therapy, and predicting HD genotype.
III. Identify, define, and describe the natural history of pathophysiologic lesions in HD.
IV. Characterize the genotypic and phenotypic expression of the HD gene.
|Study Design:||Primary Purpose: Screening|
|Study Start Date:||August 1993|
PROTOCOL OUTLINE: Participants are screened for Huntington's disease, including cerebral glucose metabolism assessment and genetic testing.
Studies include a detailed family history and neurologic, psychometric, and neurobehavioral evaluations. Imaging includes positron emission tomography with fluorodeoxyglucose and brain magnetic resonance imaging.
A genotype assessment is performed; genetic results are not disclosed to patients or relatives.
|Study Chair:||John C. Mazziotta||University of California, Los Angeles|