Longitudinal and Biological Study of Childhood Disintegrative Disorder
I. Compare the developmental course (language acquisition, diagnostic stability, predictors of outcome, and restricted interests and behaviors) of childhood disintegrative disorder versus autism and non-autistic developmental delays.
II. Collect data on molecular genetics of proband and family members.
Pervasive Child Development Disorders
|Study Design:||Primary Purpose: Screening
Time Perspective: Longitudinal
|Study Start Date:||May 1997|
Patients are evaluated with the following questionnaires at ages 2-3 years and again at ages 5-9: The Autism Diagnostic Interview (ADI); The Autism Diagnostic Observation Schedule (ADOS); Assessment of cognitive functioning; Expressive and receptive language; Adaptive functioning; Measures of burden and functional assessment; The Aberrant Behavior Checklist; The Connors Rating Scale - Parent and Teacher version; and Autism Behavior Checklist
An MRI and EEG are performed, and blood samples are collected from patients and family members for molecular genetic studies.
|United States, Connecticut|
|Yale Child Study Center|
|New Haven, Connecticut, United States, 06520|
|United States, Illinois|
|University of Chicago Cancer Research Center|
|Chicago, Illinois, United States, 60637|
|Study Chair:||Fred Volkmar||Yale University|