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Longitudinal and Biological Study of Childhood Disintegrative Disorder

This study has been terminated.
Sponsor:
Collaborator:
Yale University
Information provided by:
Office of Rare Diseases (ORD)
ClinicalTrials.gov Identifier:
NCT00004458
First received: October 18, 1999
Last updated: June 23, 2005
Last verified: October 2003
History of Changes
  Purpose

OBJECTIVES:

I. Compare the developmental course (language acquisition, diagnostic stability, predictors of outcome, and restricted interests and behaviors) of childhood disintegrative disorder versus autism and non-autistic developmental delays.

II. Collect data on molecular genetics of proband and family members.


Condition
Pervasive Child Development Disorders
Autism

Study Type: Observational
Study Design: Primary Purpose: Screening
Time Perspective: Longitudinal

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Office of Rare Diseases (ORD):

Estimated Enrollment: 220
Study Start Date: May 1997
Detailed Description:

PROTOCOL OUTLINE:

Patients are evaluated with the following questionnaires at ages 2-3 years and again at ages 5-9: The Autism Diagnostic Interview (ADI); The Autism Diagnostic Observation Schedule (ADOS); Assessment of cognitive functioning; Expressive and receptive language; Adaptive functioning; Measures of burden and functional assessment; The Aberrant Behavior Checklist; The Connors Rating Scale - Parent and Teacher version; and Autism Behavior Checklist

An MRI and EEG are performed, and blood samples are collected from patients and family members for molecular genetic studies.

  Eligibility

Ages Eligible for Study:   2 Years to 9 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria
  • Psychologically diagnosed (DSM-IV) as Childhood Disintegrative Disorder
  • No known genetic or medical syndrome (Down syndrome or cerebral palsy)
  • Must speak English
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00004458

Locations
United States, Connecticut
Yale Child Study Center
New Haven, Connecticut, United States, 06520
United States, Illinois
University of Chicago Cancer Research Center
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Yale University
Investigators
Study Chair: Fred Volkmar Yale University
  More Information

Publications:
Volkmar FR, Klin A, Marans WD, et al.: Childhood disintegrative disorder. In: Cohen DJ, Volkmar FR.: Handbook of autism and pervasive developmental disorders. 2nd ed., New York, NY: John Wiley, 1997, pp 47-59.

ClinicalTrials.gov Identifier: NCT00004458     History of Changes
Other Study ID Numbers: 199/13682, YALE-5P01HD0300830, YALE-HIC-5895
Study First Received: October 18, 1999
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Keywords provided by Office of Rare Diseases (ORD):
autism
childhood disintegrative disorder
neurologic and psychiatric disorders
rare disease

Additional relevant MeSH terms:
Autistic Disorder
Developmental Disabilities
Child Development Disorders, Pervasive
Mental Disorders Diagnosed in Childhood
Mental Disorders

ClinicalTrials.gov processed this record on May 16, 2013