Study of Pituitary Size and Function in Familial Dwarfism of Sindh
OBJECTIVES: I. Assess pituitary size and anatomic configuration by magnetic resonance imaging (MRI) in 4 affected dwarfs in the province of Sindh, Pakistan.
II. Evaluate ultradian growth hormone (GH) secretory patterns in 4 affected dwarfs.
Growth Hormone Deficiency
|Study Design:||Primary Purpose: Screening|
|Study Start Date:||September 1995|
|Estimated Study Completion Date:||February 2000|
PROTOCOL OUTLINE: Pituitary size and anatomy and growth hormone response are evaluated.
All patients undergo MRI of the pituitary fossa on day 1. On day 2, homozygous patients receive a slow infusion of normal saline with blood sampling every 10 minutes.
|Study Chair:||Gerhard Baumann||Northwestern University|