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Study of Prevalence and Clinical Phenotype in Patients With Glucocorticoid-Remediable Aldosteronism

This study has been completed.
Sponsor:
Collaborator:
Brigham and Women's Hospital
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
NCT00004354
First received: October 18, 1999
Last updated: June 23, 2005
Last verified: May 2002
History of Changes
  Purpose

OBJECTIVES: I. Determine the prevalence of glucocorticoid-remediable aldosteronism (GRA) in various hypertensive populations and screen at risk members of GRA pedigrees.

II. Investigate other factors regulating blood pressure in GRA (environmental, genetically determined factors).

III. Investigate renal and hormonal mechanisms regulating potassium homeostasis in GRA.

IV. Describe clinical phenotype of GRA patients. V. Prospectively screen GRA-affected patients with MRI angiography for intracranial aneurysm.


Condition
Hyperaldosteronism

Study Type: Observational
Study Design: Primary Purpose: Screening

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by National Center for Research Resources (NCRR):

Study Start Date: June 1999
Detailed Description:

PROTOCOL OUTLINE:

Patients are screened for high blood pressure, suppressed plasma renin activity level, and low potassium levels. Urine is collected for a 24 hour period. Blood specimen is collected for molecular biologic evaluation for the presence of the chimeric gene diagnostic of GRA. Any history of cardiovascular events is recorded.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics-- Diagnosed glucocorticoid-remediable aldosteronism (GRA) with hypertension Hypokalemia is variably seen Blood pressure variably elevated Elevated level of aldosterone Low level of plasma renin activity

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00004354

Locations
United States, Massachusetts
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Sponsors and Collaborators
National Center for Research Resources (NCRR)
Brigham and Women's Hospital
Investigators
Study Chair: Robert G. Dluhy Brigham and Women's Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00004354     History of Changes
Other Study ID Numbers: 199/11917, BWH-91328603
Study First Received: October 18, 1999
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Keywords provided by National Center for Research Resources (NCRR):
endocrine disorders
genetic diseases and dysmorphic syndromes
hyperaldosteronism
rare disease

Additional relevant MeSH terms:
Hyperaldosteronism
Adrenocortical Hyperfunction
Adrenal Gland Diseases
Endocrine System Diseases

ClinicalTrials.gov processed this record on May 21, 2013