Combination Chemotherapy in Treating Patients With Metastatic or Unresectable Solid Tumors

DISEASE CHARACTERISTICS:

• Histologically or clinically confirmed metastatic or unresectable solid tumor for which no standard curative or palliative therapy exists or is no longer
• No known brain metastases

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• ECOG 0-2

Life expectancy:

• Not specified

Hematopoietic:

• Absolute neutrophil count at least 1,500/mm3
• Platelet count at least 100,000/mm3

Hepatic:

• Bilirubin normal
• Proven Gilbert's syndrome (UGT1A1 promoter mutation or clinical
• documentation of stress bilirubin levels) allowed
• AST/ALT no greater than 3 times upper limit of normal

Renal:

• Creatinine normal OR
• Creatinine clearance at least 60 mL/min

Cardiovascular:

• No symptomatic congestive heart failure
• No unstable angina pectoris
• No cardiac arrhythmia

Pulmonary:

• No unexplained respiratory problems (e.g., nonproductive cough, dyspnea,
• rales, pulmonary infiltrates, hypoxia, or tachypnea)

Other:

• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No clinical evidence of neuropathy
• No prior allergy to platinum compounds
• No prior allergy to antiemetics appropriate for administration in
• conjunction with protocol directed chemotherapy
• No other concurrent uncontrolled illness (e.g., active infection)

PRIOR CONCURRENT THERAPY:

Chemotherapy:

• At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas and
• platinum) and recovered
• No more than 1 prior chemotherapy regimen for cancer

Radiotherapy:

• At least 4 weeks since prior radiotherapy

Other:

• No concurrent antiretroviral agents (HAART)
• No other concurrent investigational agents or commercial therapies