Biological Therapy in Treating Children With Refractory or Recurrent Neuroblastoma or Other Tumors

DISEASE CHARACTERISTICS:

• Histologically confirmed neuroblastoma or melanoma at original diagnosis

  • Refractory to chemotherapy or recurrence after prior multiagent chemotherapy
  • Measurable or evaluable (detectable by bone scan) metastatic disease OR
  • No evidence of disease if complete response to prior surgical resection, radiotherapy, and/or chemotherapy OR

• Histologically confirmed tumor expressing GD2 antigen at original diagnosis or relapse

  • Refractory to standard treatment
  • Measurable or evaluable disease by clinical assessments or laboratory markers OR
  • No evidence of disease after prior surgical resection of metastatic, recurrent disease
  • Histologically confirmed recurrent osteogenic sarcoma after prior chemotherapy allowed
  • Soft tissue sarcoma allowed
• No primary CNS tumors

• Prior CNS metastases allowed, provided:

  • Disease previously treated
  • Disease clinically stable for 4 weeks before study
  • At least 4 weeks since prior steroids for CNS metastases
• No clinically detectable pleural effusions or ascites

PATIENT CHARACTERISTICS:

Age:

• 21 and under

Performance status:

• Karnofsky 60-100% for children over age 10
• Lansky 60-100% for children age 10 and under

Life expectancy:

• At least 12 weeks

Hematopoietic:

• Absolute neutrophil count greater than 1,000/mm^3
• Platelet count at least 75,000/mm^3 (transfusion allowed)
• Hemoglobin at least 9.0 g/dL (transfusion allowed)

Hepatic:

• Bilirubin less than 1.5 mg/dL
• ALT or AST no greater than 2.5 times normal
• Hepatitis B surface antigen negative

Renal:

• Creatinine no greater than 1.5 mg/dL OR
• Creatinine clearance or radioisotope glomerular filtration rate at least 60 mL/min

Cardiovascular:

• Shortening fraction at least 27% by echocardiogram OR
• Ejection fraction more than 50% by MUGA scan
• No congestive heart failure
• No uncontrolled cardiac rhythm disturbance

Pulmonary:

• FEV_1 and FVC more than 60% of predicted OR
• No dyspnea at rest
• No exercise intolerance
• Oxygen saturation more than 94% by pulse oximetry on room air

Neurologic:

• No seizure disorders requiring antiseizure medications
• No significant neurologic deficit or grade 2 or greater objective peripheral neuropathy

Other:

• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• HIV negative
• No significant concurrent illnesses unrelated to cancer or its treatment
• No significant psychiatric disabilities
• No uncontrolled active infections
• No uncontrolled active peptic ulcer

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• At least 1 week since prior growth factors
• At least 1 week since prior immunomodulatory therapy
• Prior monoclonal antibodies allowed if no detectable antibody to hu14.18
• Prior autologous bone marrow transplantation (BMT) or stem cell transplantation (SCT) allowed
• Prior autologous BMT or SCT with monoclonal antibody-purged specimens allowed
• No concurrent growth factors
• No concurrent interferon

Chemotherapy:

• See Disease Characteristics
• At least 3 weeks since prior chemotherapy (6 weeks for nitrosoureas, mitomycin, or melphalan)
• No concurrent palliative chemotherapy

Endocrine therapy:

• See Disease Characteristics
• At least 2 weeks since prior glucocorticoids, except for life-threatening symptoms
• No concurrent corticosteroids
• No concurrent glucocorticoids, except for life-threatening symptoms

Radiotherapy:

• See Disease Characteristics
• At least 3 weeks since prior radiotherapy
• No concurrent palliative radiotherapy

Surgery:

• See Disease Characteristics
• At least 2 weeks since prior major surgery (e.g., laparotomy or thoracotomy)
• No prior organ allografts
• No concurrent palliative surgery

Other:

• Recovered from prior therapy
• At least 1 week since prior tretinoin
• At least 3 weeks since prior immunosuppressive therapy
• No other concurrent immunosuppressive drugs