Interleukin-2 in Treating Patients With Mycosis Fungoides

DISEASE CHARACTERISTICS:

• Clinically and histologically proven diagnosis of 1 of the following:

  • Mycosis fungoides (MF) meeting 1 of the following conditions:

    • Stage IIB disease that has failed psoralen ultraviolet A (PUVA) light therapy and topical chemotherapy (mechlorethamine and/or carmustine)
    • Stage III disease with generalized erythroderma
    • Stage IV disease with biopsy proven nodal or visceral involvement

  • Sezary syndrome

    • Stage III MF with a minimum of 20% Sezary cells (based on total WBC)

• No clinically significant ascites or pleural effusion

  • Clinically significant pleural effusion defined as shortness of breath with oxygen saturation less than 90%

PATIENT CHARACTERISTICS:

Age:

• 18 to 80

Performance status:

• Karnofsky 70-100%

Life expectancy:

• At least 16 weeks

Hematopoietic:

• See Disease Characteristics
• WBC at least 3,500/mm^3
• Granulocyte count at least 1,500/mm^3
• Platelet count at least 100,000/mm^3
• Hemoglobin at least 11.5 g/dL

Hepatic:

• Bilirubin less than 2.5 times normal
• SGOT less than 2.5 times normal

Renal:

• Creatinine no greater than 2.0 mg/dL
• No nephrotic syndrome

Cardiovascular:

• No history of myocardial infarction or congestive heart failure
• No symptomatic coronary artery disease
• No clinically manifest hypotension
• No severe hypertension
• No arrhythmia on electrocardiogram
• No edema
• No contraindication to pressor agents

Pulmonary:

• See Disease Characteristics
• No dyspnea at rest or severe exertional dyspnea

Neurologic:

• No significant CNS dysfunction, including any of the following:

  • Seizure disorder
  • Active cerebrovascular disease
  • Dementia or delirium

Other:

• No autoimmune disease, including psoriasis
• No uncontrolled peptic ulcer disease
• No uncontrolled infection
• No history of adverse reaction to interleukin-2
• HIV and HTLV-I negative
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• See Disease Characteristics
• At least 4 weeks since prior systemic or topical chemotherapy (6 weeks since prior mitomycin or nitrosoureas)

Endocrine therapy:

• At least 1 week since prior corticosteroids
• No concurrent corticosteroids

Radiotherapy:

• At least 4 weeks since prior radiotherapy

Surgery:

• No prior organ allograft
• At least 3 weeks since other prior major surgery

Other:

• At least 4 weeks since prior immunosuppressive therapy
• At least 2 weeks since prior phototherapy (ultraviolet B [UVB] or PUVA light therapy)
• No concurrent phototherapy (UVB or PUVA light therapy)