Collection of Blood and Bone Marrow From Healthy Volunteers and Patients for Research Purposes

This study has been completed.
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00001627
First received: November 3, 1999
Last updated: March 14, 2014
Last verified: November 2013
  Purpose

This study is designed to provide bone marrow and/or blood cells for other research studies. Patients participating in this study will be asked to provide small amounts of medical information and undergo a limited physical examination designed to detect the presence of any obvious blood disease. A blood and bone marrow sample will be obtained to verify that the patient has normal blood cell production.

Researchers plan to obtain bone marrow samples to be used in laboratory studies directed toward understanding the formation of blood cells. Bone marrow samples will be taken from the hip bone of patients and healthy volunteers.

These samples are valuable to many research studies within the Hematology Branch of the National Heart, Lung, and Blood Institute, including studies of normal and abnormal production of blood cells, the viral causes of blood diseases, and the role of the immune system in bone marrow failure and related conditions.


Condition
Aplastic Anemia
Fanconi's Anemia
Healthy
Hematologic Disease
Myelodysplastic Syndrome

Study Type: Observational
Official Title: Collection of Blood and Bone Marrow From Healthy Volunteers and Patients for Research Purposes

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Enrollment: 154
Study Start Date: June 1997
Detailed Description:

This protocol defines in general terms the purposes for which blood and bone marrow specimens will be collected by members of the Hematology Branch and the conditions under which the sampling will be performed. Samples of blood and bone marrow from healthy volunteers and from patients are indispensable for many research projects, including studies of normal and abnormal hematopoiesis, the viral etiology of blood diseases, and the role of the immune system in marrow failure and related conditions.

  Eligibility

Ages Eligible for Study:   2 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria
  • INCLUSION CRITERIA:

Healthy volunteers age greater than or equal to 18 years.

Subjects with hematologic disease age greater than or equal to 2 (for subjects less than 18, blood and bone marrow specimens will be obtained concurrently with clinically indicated sampling).

EXCLUSION CRITERIA:

History of a significant bleeding disorder.

Abnormal host-defense mechanisms.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00001627

Locations
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
Investigators
Principal Investigator: Neal S Young, M.D. National Heart, Lung, and Blood Institute (NHLBI)
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00001627     History of Changes
Other Study ID Numbers: 970130, 97-H-0130
Study First Received: November 3, 1999
Last Updated: March 14, 2014
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Bone Marrow
Hematopoiesis
DNA
RNA
Viruses
Normal Volunteer
Aplastic Anemia
Myelodysplasia
Fanconi's Anemia
Single Lineage Cytopenia

Additional relevant MeSH terms:
Anemia
Myelodysplastic Syndromes
Preleukemia
Anemia, Aplastic
Hematologic Diseases
Fanconi Anemia
Fanconi Syndrome
Bone Marrow Diseases
Precancerous Conditions
Neoplasms
Anemia, Hypoplastic, Congenital
Genetic Diseases, Inborn
DNA Repair-Deficiency Disorders
Metabolic Diseases
Kidney Diseases
Urologic Diseases
Renal Tubular Transport, Inborn Errors
Metabolism, Inborn Errors

ClinicalTrials.gov processed this record on September 18, 2014