Multimodal Treatment Study of Children With Attention Deficit and Hyperactivity Disorder (MTA)

This study has been completed.
Sponsor:
Collaborator:
Information provided by:
New York University School of Medicine
ClinicalTrials.gov Identifier:
NCT00000388
First received: November 2, 1999
Last updated: June 27, 2013
Last verified: June 2013
  Purpose

This trial is a continuation of the Multimodal Treatment Study of Children with Attention Deficit Hyperactivity Disorder (MTA Study). Continuation Aim 1 is to track the persistence of intervention-related effects as the MTA sample matures into mid-adolescence, including subsequent mental-health and school-related service utilization patterns as a function of MTA treatment experience (treatment assignment) and outcome (degree of treatment success at 14 mo.). Aim 2 is to test specific hypotheses about predictors, mediators, and moderators of long-term outcome among children with ADHD (e.g., comorbidity; family functioning; cognitive skills; peer relations) that may influence adolescent functioning (either independent of or through initial treatment assignment and/or 14-month treatment outcomes); and to compare how these predictors, mediators, and moderators are similar or dissimilar within the normal comparison group. Aim 3 is to track the patterns of risk and protective factors (including their mediation or moderation by initial treatment assignment and/or outcome) involved in early and subsequent stages of developing substance-related disorders and antisocial behavior. Aim 4 is to examine the effect of initial treatment assignment and degree of treatment success on later academic performance, achievement, school conduct, tendency to drop out, and other adverse school outcomes.

In the original MTA design, patients were randomly assigned to 1 of 4 treatment conditions: (1) medication only; (2) psychosocial only; (3) combined (medication and psychosocial); or (4) Assessment-and-Referral condition. All but the latter were treated intensively for 14 months, with assessments for all subjects at baseline, 3, 9, 14, and 24 months. The original MTA design thus provides short-term (10 months post-treatment) follow-up at 24 months. This continuation extends the follow-up to assessments at 36, 60, and 84 months after treatment.

A child may be eligible for this study if he/she:

Is 7 - 9 years old, and has Attention Deficit Hyperactivity Disorder (ADHD).


Condition Intervention Phase
Attention Deficit Disorder With Hyperactivity
Substance-related Disorders
Dyssocial Behavior
Behavioral: Psychosocial treatment
Drug: Anti-ADHD medication
Behavioral: Assessment-and-Referral
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Primary Purpose: Treatment
Official Title: Multimodal Treatment Study of Children With ADHD

Resource links provided by NLM:


Further study details as provided by New York University School of Medicine:

Study Start Date: September 1998
Estimated Study Completion Date: November 1999
Detailed Description:

This trial is a continuation of the Multimodal Treatment Study of Children with Attention Deficit Hyperactivity Disorder (MTA Study). Continuation Aim 1 is to track the persistence of intervention-related effects as the MTA sample matures into mid-adolescence, including subsequent mental-health and school-related service utilization patterns as a function of MTA treatment experience (treatment assignment) and outcome (degree of treatment success at 14 mo.). Aim 2 is to test specific hypotheses about predictors, mediators, and moderators of long-term outcome among children with ADHD (e.g., comorbidity; family functioning; cognitive skills; peer relations) that may influence adolescent functioning (either independent of or through initial treatment assignment and/or 14-month treatment outcomes); and to compare how these predictors, mediators, and moderators are similar or dissimilar within the normal comparison group. Aim 3 is to track the patterns of risk and protective factors (including their mediation or moderation by initial treatment assignment and/or outcome) involved in early and subsequent stages of developing substance-related disorders and antisocial behavior. Aim 4 is to examine the effect of initial treatment assignment and degree of treatment success on later academic performance, achievement, school conduct, tendency to drop out, and other adverse school outcomes.

In the original MTA design, patients were randomly assigned to 1 of 4 treatment conditions: (1) medication only; (2) psychosocial only; (3) combined (medication and psychosocial); or (4) Assessment-and-Referral condition. All but the latter were treated intensively for 14 months, with assessments for all subjects at baseline, 3, 9, 14, and 24 months. The original MTA design thus provides short-term (10 months post-treatment) follow-up at 24 months. This continuation extends the follow-up to assessments at 36, 60, and 84 months after treatment.

  Eligibility

Ages Eligible for Study:   7 Years to 9 Years
Genders Eligible for Study:   Both
Criteria

Inclusion Criteria:

-

Patients must have:

Rigorously diagnosed Attention Deficit Hyperactivity Disorder (ADHD).

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00000388

Sponsors and Collaborators
New York University School of Medicine
Investigators
Principal Investigator: Howard B. Abikoff, PhD
Principal Investigator: C. Keith Conners
Principal Investigator: Laurence L. Greenhill, MD
Principal Investigator: Stephen P. Hinshaw, PhD
Principal Investigator: William E. Pelham, PhD
Principal Investigator: James M. Swanson, PhD
  More Information

Publications:
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

ClinicalTrials.gov Identifier: NCT00000388     History of Changes
Other Study ID Numbers: U01 MH050453, U01MH050453, MH50447, MH50454, MH50461, MH50467, MH50440, DSIR CT
Study First Received: November 2, 1999
Last Updated: June 27, 2013
Health Authority: United States: Federal Government

Keywords provided by New York University School of Medicine:
Attention Deficit Disorder with Hyperactivity
Adolescence
Child
Cognition
Combined Modality Therapy
Female
Human
Male
Peer Group
Risk Factors
Treatment Outcome
Attention Deficit Disorder with Hyperactivity -- *therapy
Attention Deficit Disorder with Hyperactivity -- drug therapy
Attention Deficit Disorder with Hyperactivity -- psychology

Additional relevant MeSH terms:
Antisocial Personality Disorder
Attention Deficit Disorder with Hyperactivity
Substance-Related Disorders
Hyperkinesis
Personality Disorders
Mental Disorders
Attention Deficit and Disruptive Behavior Disorders
Mental Disorders Diagnosed in Childhood
Dyskinesias
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on April 22, 2014