Effects of Carvedilol on Cocaine Use in Humans - 11
The purpose of this study is to examine carvedilol effects in response to cocaine.
|Study Design:||Masking: Double-Blind
Primary Purpose: Treatment
|Official Title:||Effects of Carvedilol on Cocaine Use in Humans|
- Physiologic measures
|Study Start Date:||September 1998|
|Estimated Study Completion Date:||December 2001|
The purpose of this study was to determine whether carvedilol, and alpha and beta adrenergic blocker, would inhibit the priming effect of cocaine in a laboratory model. A total of 12 subjects were enrolled in this double blind, placebo controlled, outpatient study. After an adaptation session, three experimental sessions were held, 2-9 days apart. On each of 3 experimental sessions, a single oral dose of low (25mg) or high dose of carvedilol (50mg) or placebo were administered. Two hours following carvedilol or placebo treatment, subjects received a priming dose of smoked cocaine, 0.4 mg/kg. during the second part of the session, subjects had the option to earn up to 2 tokens by working on a computer task that could later be exchanged for money or deliveries of cocaine. We proposed that blockage of adrenergic receptors by carvedilol would significantly alter the subjective and physiological effects of cocaine.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00000294
|United States, Minnesota|
|University of Minnesota|
|Minneapolis, Minnesota, United States, 55455|
|Principal Investigator:||Dorothy Hatsukami, Ph.D.||University of Minnesota - Clinical and Translational Science Institute|