Role of Metabolites in Nicotine Dependence (3) - 6
The purpose of this study is to determine the effects of various doses of ondansetron transdermal nicotine replacement on tobacco withdrawal symptoms.
|Study Design:||Masking: Double-Blind
Primary Purpose: Treatment
|Official Title:||Role of Metabolites in Nicotine Dependence (3)|
- Subjective effects
- Physiological effects
- Performance effects
|Study Start Date:||May 1998|
|Estimated Study Completion Date:||December 2001|
Previous studies have shown that cotinine, a metabolite of nicotine, antagonizes the beneficial effects of the nicotine patch in redugin withdrawal symptoms. Studies have also shown that cotinine enhances serotonin levels. This study examined the effects of several doses of a 5HT3 antagonist, ondanstron, in combination with the nicotine patch. This medication has been observed to reduce nicotine withdrawal symptoms in rats. These effects were compared to the nicotine patch alone. The results of this study produced some modest effects showing that the 8mg dose of ondansetron suppressed tobacco withdrawal symptoms to a greater extent than the nicotine patch alone.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00000289
|United States, Minnesota|
|University of Minnesota|
|Minneapolis, Minnesota, United States, 55455|
|Principal Investigator:||Dorothy Hatsukami, Ph.D.||University of Minnesota - Clinical and Translational Science Institute|