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Subjective/Psychomotor/ Effects of Combined Alcohol & Nitrous Oxide - 16

This study has been completed.
Information provided by (Responsible Party):
University of Chicago Identifier:
First received: September 20, 1999
Last updated: July 23, 2013
Last verified: July 2013

The purpose of this study is to examine the subjective, psychomotor, and reinforcing effects of combined alcohol and nitrous oxide intake in healthy volunteers.

Condition Intervention
Opioid-Related Disorders
Substance-Related Disorders
Drug: 30% Nitrous oxide
Other: 0.35 g/Kg ethanol
Other: 0.7 g/Kg ethanol
Other: 0 g/Kg ethanol

Study Type: Interventional
Study Design: Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Caregiver)
Official Title: Subjective/Psychomotor/ Effects of Combined Alcohol & Nitrous Oxide

Resource links provided by NLM:

Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Mood [ Time Frame: Baseline and post inhalation ] [ Designated as safety issue: No ]
  • Psychomotor performance [ Time Frame: Baseline and post inhalation ] [ Designated as safety issue: No ]
  • Cognitive performance [ Time Frame: Baseline and post inhalation ] [ Designated as safety issue: No ]
  • Choice of nitrous oxide vs placebo [ Time Frame: after each ethanol session ] [ Designated as safety issue: No ]

Enrollment: 8
Study Start Date: September 1997
Study Completion Date: October 1999
Primary Completion Date: October 1999 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: 0 g/Kg ethanol +/- 30% nitrous oxide Drug: 30% Nitrous oxide Other: 0 g/Kg ethanol
Active Comparator: 0.35 g/Kg ethanol +/- 30% nitrous oxide Drug: 30% Nitrous oxide Other: 0.35 g/Kg ethanol
Active Comparator: 0.7 g/Kg ethanol +/- 30% nitrous oxide Drug: 30% Nitrous oxide Other: 0.7 g/Kg ethanol


Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

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Please refer to this study by its identifier: NCT00000264

United States, Illinois
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
Principal Investigator: James Zacny, Ph.D. University of Chicago
  More Information

No publications provided

Responsible Party: University of Chicago Identifier: NCT00000264     History of Changes
Other Study ID Numbers: NIDA-08391-16, R01DA008391, R01-08391-16
Study First Received: September 20, 1999
Last Updated: July 23, 2013
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Pathologic Processes
Nitrous Oxide
Analgesics, Non-Narcotic
Anesthetics, General
Anesthetics, Inhalation
Anti-Infective Agents
Anti-Infective Agents, Local
Central Nervous System Agents
Central Nervous System Depressants
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Sensory System Agents
Therapeutic Uses processed this record on November 27, 2014