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Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide - 13

This study has been completed.
Information provided by (Responsible Party):
University of Chicago Identifier:
First received: September 20, 1999
Last updated: July 23, 2013
Last verified: July 2013

The purpose of this study is to evaluate the effects of alcohol history on the subjective and reinforcing effects of sevoflurane and nitrous oxide in healthy volunteers. All subjects underwent psychomotor testing during 4 sessions of placebo, drug/placebo, and choice of intervention.

Condition Intervention Phase
Alcohol-Related Disorders
Opioid-Related Disorders
Substance-Related Disorders
Drug: 30% Nitrous oxide
Other: Placebo
Drug: 0.2% sevoflurane
Drug: 0.4% sevoflurane
Drug: 0.6% sevoflurane
Phase 2

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Caregiver)
Official Title: Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide

Resource links provided by NLM:

Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Mood [ Time Frame: Baseline, inhalation, recovery ] [ Designated as safety issue: No ]
  • Psychomotor performance [ Time Frame: Baseline, inhalation, recovery ] [ Designated as safety issue: No ]
  • Choice of drug vs placebo [ Time Frame: After placebo and drug in each session ]

Enrollment: 14
Study Start Date: November 1997
Study Completion Date: October 1998
Primary Completion Date: October 1998 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Moderate drinking adults Drug: 30% Nitrous oxide Other: Placebo
No drug (100% oxygen)
Drug: 0.2% sevoflurane Drug: 0.4% sevoflurane Drug: 0.6% sevoflurane


Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

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Please refer to this study by its identifier: NCT00000261

United States, Illinois
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
Principal Investigator: James Zacny, Ph.D. University of Chicago
  More Information

No publications provided

Responsible Party: University of Chicago Identifier: NCT00000261     History of Changes
Other Study ID Numbers: NIDA-08391-13, R01DA008391, R01-08391-13
Study First Received: September 20, 1999
Last Updated: July 23, 2013
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Alcohol-Related Disorders
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Pathologic Processes
Nitrous Oxide
Analgesics, Non-Narcotic
Anesthetics, General
Anesthetics, Inhalation
Central Nervous System Agents
Central Nervous System Depressants
Hematologic Agents
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Platelet Aggregation Inhibitors
Sensory System Agents
Therapeutic Uses processed this record on November 24, 2014