Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide - 13

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
University of Chicago
ClinicalTrials.gov Identifier:
NCT00000261
First received: September 20, 1999
Last updated: July 23, 2013
Last verified: July 2013
  Purpose

The purpose of this study is to evaluate the effects of alcohol history on the subjective and reinforcing effects of sevoflurane and nitrous oxide in healthy volunteers. All subjects underwent psychomotor testing during 4 sessions of placebo, drug/placebo, and choice of intervention.


Condition Intervention Phase
Alcohol-Related Disorders
Opioid-Related Disorders
Substance-Related Disorders
Drug: 30% Nitrous oxide
Other: Placebo
Drug: 0.2% sevoflurane
Drug: 0.4% sevoflurane
Drug: 0.6% sevoflurane
Phase 2

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Caregiver)
Official Title: Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide

Resource links provided by NLM:


Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Mood [ Time Frame: Baseline, inhalation, recovery ] [ Designated as safety issue: No ]
  • Psychomotor performance [ Time Frame: Baseline, inhalation, recovery ] [ Designated as safety issue: No ]
  • Choice of drug vs placebo [ Time Frame: After placebo and drug in each session ]

Enrollment: 14
Study Start Date: November 1997
Study Completion Date: October 1998
Primary Completion Date: October 1998 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Moderate drinking adults Drug: 30% Nitrous oxide Other: Placebo
No drug (100% oxygen)
Drug: 0.2% sevoflurane Drug: 0.4% sevoflurane Drug: 0.6% sevoflurane

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Please contact site for information.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00000261

Locations
United States, Illinois
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
Investigators
Principal Investigator: James Zacny, Ph.D. University of Chicago
  More Information

No publications provided

Responsible Party: University of Chicago
ClinicalTrials.gov Identifier: NCT00000261     History of Changes
Other Study ID Numbers: NIDA-08391-13, R01DA008391, R01-08391-13
Study First Received: September 20, 1999
Last Updated: July 23, 2013
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Disease
Substance-Related Disorders
Opioid-Related Disorders
Alcohol-Related Disorders
Pathologic Processes
Chemically-Induced Disorders
Mental Disorders
Sevoflurane
Nitrous Oxide
Platelet Aggregation Inhibitors
Hematologic Agents
Therapeutic Uses
Pharmacologic Actions
Anesthetics, Inhalation
Anesthetics, General
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs
Central Nervous System Agents
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents

ClinicalTrials.gov processed this record on September 29, 2014