Effects of Alcohol History on Effects of Nitrous Oxide - 9

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
University of Chicago
ClinicalTrials.gov Identifier:
NCT00000257
First received: September 20, 1999
Last updated: July 23, 2013
Last verified: July 2013
  Purpose

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To determine effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers.


Condition Intervention
Alcohol-Related Disorders
Opioid-Related Disorders
Substance-Related Disorders
Drug: 0% N2O and 10% N2O
Drug: 0% N2O and 20% N2O
Drug: 0% N2O and 30% N2O
Drug: 0% N2O and 40% N2O

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Official Title: Effects of Alcohol History on Effects of Nitrous Oxide

Resource links provided by NLM:


Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Choice of nitrous oxide vs placebo [ Time Frame: After 30 min inhalation each of N2O and placebo ] [ Designated as safety issue: No ]
    Two subject groups (light drinkers vs moderate drinkers) were asked to inhale a given conc of N2O and inhale a placebo, then choose for a third inhalation. The subject & the technician administering the inhalant were blinded. Testing was done at each dose.


Enrollment: 19
Study Start Date: September 1995
Study Completion Date: April 1997
Primary Completion Date: April 1997 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Light drinkers Drug: 0% N2O and 10% N2O Drug: 0% N2O and 20% N2O Drug: 0% N2O and 30% N2O Drug: 0% N2O and 40% N2O
Active Comparator: Moderate drinkers Drug: 0% N2O and 10% N2O Drug: 0% N2O and 20% N2O Drug: 0% N2O and 30% N2O Drug: 0% N2O and 40% N2O

  Eligibility

Ages Eligible for Study:   21 Years to 37 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Please contact site for information.

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00000257

Locations
United States, Illinois
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
Investigators
Principal Investigator: James Zacny, Ph.D. University of Chicago
  More Information

No publications provided

Responsible Party: University of Chicago
ClinicalTrials.gov Identifier: NCT00000257     History of Changes
Other Study ID Numbers: NIDA-08391-9, R01DA008391, R01-08391-9
Study First Received: September 20, 1999
Last Updated: July 23, 2013
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Alcohol-Related Disorders
Disease
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Pathologic Processes
Nitrous Oxide
Analgesics
Analgesics, Non-Narcotic
Anesthetics
Anesthetics, General
Anesthetics, Inhalation
Central Nervous System Agents
Central Nervous System Depressants
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Sensory System Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on October 23, 2014