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Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7

This study has been completed.
Sponsor:
Collaborator:
National Institute on Drug Abuse (NIDA)
Information provided by:
University of Chicago
ClinicalTrials.gov Identifier:
NCT00000255
First received: September 20, 1999
Last updated: October 5, 2011
Last verified: November 1995
History of Changes
  Purpose

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine differential acute tolerance development to effects of nitrous oxide in humans.


Condition Intervention Phase
Opioid-Related Disorders
Substance-Related Disorders
 Drug: Nitrous oxide
 Phase 2

Study Type: Interventional
Study Design: Primary Purpose: Treatment
Official Title: Differential Acute Tolerance Development to Effects of Nitrous Oxide

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Pain intensity, pain bothersomeness
  • Mood
  • Psychomotor performance
  • Pain quality

Estimated Enrollment: 0
Study Start Date: April 1995
  Eligibility

Ages Eligible for Study:   21 Years to 37 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Please contact site for information.

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00000255

Locations
United States, Illinois
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
National Institute on Drug Abuse (NIDA)
Investigators
Principal Investigator: James Zacny, Ph.D. University of Chicago
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00000255     History of Changes
Other Study ID Numbers: NIDA-08391-7, R01DA008391, R01-08391-7
Study First Received: September 20, 1999
Last Updated: October 5, 2011
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Opioid-Related Disorders
Substance-Related Disorders
Mental Disorders
Nitrous Oxide
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
 Physiological Effects of Drugs
Pharmacologic Actions
Central Nervous System Agents
Therapeutic Uses
Anesthetics, Inhalation
Anesthetics, General
Anesthetics
Central Nervous System Depressants

ClinicalTrials.gov processed this record on May 23, 2013