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Effects of Subanesthetic Concentrations of Nitrous Oxide - 1

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
University of Chicago
ClinicalTrials.gov Identifier:
NCT00000249
First received: September 20, 1999
Last updated: July 23, 2013
Last verified: July 2013
  Purpose

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans.


Condition Intervention Phase
Opioid-Related Disorders
Substance-Related Disorders
Drug: 20% N2O
Drug: 30% N2O
Drug: 40% N2O
Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
Official Title: Effects of Subanesthetic Concentrations of Nitrous Oxide

Resource links provided by NLM:


Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Pain intensity [ Time Frame: during cold test at 10 min & 30 min of inhalation ] [ Designated as safety issue: No ]
    Subjects immersed non-dominant arm for 3 minutes twice in 2-3 degree C water while inhaling 0 (placebo), 20, 30, or 40% N2O for a total of 40 minutes


Enrollment: 10
Study Start Date: September 1993
Study Completion Date: June 1995
Primary Completion Date: June 1995 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
No Intervention: Control
Subject inhaled 0% N2O for 40 minutes with cold immersion at 10 and 30 minutes
Active Comparator: 20% N2O
Subject inhaled 20% N2O for 40 minutes with cold immersion at 10 & 30 minutes
Drug: 20% N2O
20% inhaled N2O
Active Comparator: 30% N2O
Subject inhaled 30% N2O for 40 minutes with cold immersion at 10 and 30 minutes
Drug: 30% N2O
30% inhaled N2O
Active Comparator: 40% N2O
Subject inhaled 40% N2O for 40 minutes with cold immersion at 10 and 30 minutes
Drug: 40% N2O
40% inhaled N2O

  Eligibility

Ages Eligible for Study:   21 Years to 37 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Please contact site for information.

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00000249

Locations
United States, Illinois
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
Investigators
Principal Investigator: James Zacny, Ph.D. University of Chicago
  More Information

No publications provided

Responsible Party: University of Chicago
ClinicalTrials.gov Identifier: NCT00000249     History of Changes
Other Study ID Numbers: NIDA-08391-1, R01DA008391, R01-08391-1
Study First Received: September 20, 1999
Last Updated: July 23, 2013
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Disease
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Pathologic Processes
Nitrous Oxide
Analgesics
Analgesics, Non-Narcotic
Anesthetics
Anesthetics, General
Anesthetics, Inhalation
Central Nervous System Agents
Central Nervous System Depressants
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Sensory System Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on November 24, 2014