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Alzheimer's Disease Prevention Trial

This study has been completed.
Sponsor:
Information provided by:
National Institute on Aging (NIA)
ClinicalTrials.gov Identifier:
NCT00000176
First received: October 29, 1999
Last updated: November 3, 2010
Last verified: November 2010
  Purpose

This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's disease in women with a family history of Alzheimer's disease.


Condition Intervention Phase
Alzheimer Disease
Memory Disorders
Drug: Estrogen
Drug: Estrogen and Progesterone
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Masking: Double-Blind
Primary Purpose: Prevention
Official Title: Alzheimer's Disease Prevention Trial. A Multi-center, Randomized, Double-blind Placebo Controlled Trial of Estrogens to Prevent Alzheimer's Disease and Loss of Memory in Women.

Resource links provided by NLM:


Further study details as provided by National Institute on Aging (NIA):

Study Completion Date: September 2007
Primary Completion Date: September 2007 (Final data collection date for primary outcome measure)
Detailed Description:

PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease.

  Eligibility

Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy women 65 or older with a family history of memory problems not currently on estrogen.

Exclusion Criteria:

  • Significant neurological impairment
  • Current estrogen use
  • History of breast cancer
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00000176

Locations
United States, Alabama
University of Alabama
Birmingham, Alabama, United States, 35294
United States, California
University of California, Irvine
Irvine, California, United States, 29697-4540
United States, Connecticut
New England Center for Headache
Stamford, Connecticut, United States, 06902-1249
United States, District of Columbia
Howard University
Washington, District of Columbia, United States, 20060
United States, Florida
Lee Memorial Health System
Fort Myers, Florida, United States, 33901
Mayo Clinic Jacksonville
Jacksonville, Florida, United States, 32225
Wein Center
Miami Beach, Florida, United States, 33140
West Florida Regional Medical Center
Pensacola, Florida, United States, 32514
North Broward Medical Center
Pompano Beach, Florida, United States
Tallahassee Memorial Health Center
Tallahassee, Florida, United States, 32308
St. Mary's Medical Center
West Palm Beach, Florida, United States, 33407
United States, Maryland
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21224
United States, New Jersey
Neurology Group of Bergen County
Ridgewood, New Jersey, United States, 07450
United States, New York
Columbia University
New York, New York, United States, 10032
Cornell Medical Center, New York Presbyterian Medical Center
New York, New York, United States
New York United Hospital Medical Center
Port Chester, New York, United States, 10573
Burke Medical Research Institute
White Plains, New York, United States, 10605
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710
United States, Oklahoma
Clinical Pharmaceutical Trials
Tulsa, Oklahoma, United States, 74104-5428
United States, Rhode Island
Butler Hospital, Rhode Island Hospital
Providence, Rhode Island, United States, 02906
United States, South Carolina
Medical University of South Carolina
North Charleston, South Carolina, United States, 29406
United States, Virginia
Eastern Virginia Medical School
Norfolk, Virginia, United States, 23507-1912
Sponsors and Collaborators
Investigators
Principal Investigator: Mary Sano, PhD Mount Sinai School of Medicine
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00000176     History of Changes
Other Study ID Numbers: IA0018, RO 1AG15922-01
Study First Received: October 29, 1999
Last Updated: November 3, 2010
Health Authority: United States: Federal Government

Keywords provided by National Institute on Aging (NIA):
Alzheimer's disease
memory loss
Estrogen

Additional relevant MeSH terms:
Alzheimer Disease
Memory Disorders
Brain Diseases
Central Nervous System Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Dementia
Mental Disorders
Nervous System Diseases
Neurobehavioral Manifestations
Neurodegenerative Diseases
Neurologic Manifestations
Signs and Symptoms
Tauopathies
Estrogens
Progesterone
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Pharmacologic Actions
Physiological Effects of Drugs
Progestins

ClinicalTrials.gov processed this record on November 20, 2014