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Found 49 studies with search of: t-cell transplant depletion | Open Studies
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Rank Status Study
1 Recruiting T-cell Depleted Alternative Donor Transplantation
Conditions: Acute Lymphoblastic Leukemia;   Acute Myeloid Leukemia;   Chronic Myeloid Leukemia;   Myelodysplastic Syndrome;   Lymphomas;   Bone Marrow Failure;   Hemoglobinopathy;   Immune Deficiency;   Osteopetrosis
Intervention: Device: CliniMACS® (T cell depletion)
Age Groups: Child / Adult
First Received Date: August 28, 2009
2 Recruiting Unrelated/Partially Matched Related Donor Peripheral Stem Cell Transplantation With CliniMACs Device for T-cell Depletion
Conditions: Leukemia;   Bone Marrow Transplantation;   Immunodeficiencies
Intervention: Device: CliniMACs
Age Groups: Child / Adult
First Received Date: December 19, 2007
3 Recruiting Efficacy and Safety of Donor Lymphocytes Depleted of Alloreactive T-cells (ATIR™) in Patients Undergoing a Peripheral Blood Stem Cell Transplant From a Related, Haploidentical Donor
Conditions: Myeloid Leukemia;   Lymphoblastic Leukemia;   Lymphoma;   Multiple Myeloma;   Myelodysplastic Syndrome;   Myeloproliferative Disorders
Intervention: Biological: Donor lymphocytes depleted of alloreactive T-cells
Group: Adult
First Received Date: August 26, 2009
4 Recruiting Mismatched Family Member Donor Transplantation for Children and Young Adults With High Risk Hematological Malignancies
Conditions: Leukemia, Acute Lymphocytic (ALL);   Leukemia, Myeloid, Acute(AML);   Leukemia, Myeloid, Chronic(CML);   Juvenile Myelomonocytic Leukemia (JMML);   Hemoglobinuria, Paroxysmal Nocturnal (PNH);   Hodgkin Lymphoma;   Lymphoma, Non-Hodgkin (NHL);   Myelodysplastic Syndrome (MDS)
Interventions: Device: CliniMACS;   Procedure: Stem cell transplantation;   Drug: Systemic chemotherapy and antibodies
Age Groups: Child / Adult
First Received Date: November 29, 2007
5 Recruiting Efficacy Study of T Cell Depleted Allogeneic Non-Myeloablative Stem Cell Transplant
Conditions: Hodgkin's Disease;   Non Hodgkin's Lymphoma;   Myeloma;   Leukemia;   Myelodysplasia
Intervention: Procedure: Non-myeloablative Stem Cell Transplantation
Age Groups: Adult / Senior
First Received Date: January 14, 2008
6 Recruiting T-Cell Depletion and Stem Cell Transplant for Immune Deficiencies and Histiocytic Disorders
Conditions: Hemophagocytic Lymphohistiocytosis;   X-Linked Lymphoproliferative Disorders;   Chediak-Higashi Syndrome;   Griscelli Syndrome;   Immunologic Diseases;   Langerhans-Cell Histiocytosis;   Hematologic Diseases
Interventions: Procedure: Stem Cell Transplant;   Drug: Myeloablative conditioning regimen
Age Groups: Child / Adult
First Received Date: September 12, 2005
7 Recruiting Unrelated Cord Blood Transplant Plus a Haplo-Identical (Half-Matched), T-Cell Depleted Stem Transplant From a Related Donor for Subjects With High Risk Malignancies
Conditions: Hematologic Malignancy;   MDS;   Aplastic Anemia
Intervention: Procedure: haplo/cord transplant
Age Groups: Child / Adult
First Received Date: December 27, 2007
8 Recruiting T-Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Hematologic Malignancies
Conditions: Acute Myelogenous Leukemia;   Lymphoid Leukemia;   Chronic Myelogenous Leukemia;   Malignant Lymphoma;   Hodgkin's Disease;   Chronic Lymphocytic Leukemia;   Myeloproliferative Disorder;   Anemia, Aplastic;   Myelodysplastic Syndromes
Interventions: Drug: Fludarabine;   Drug: Melphalan;   Drug: Stem cells;   Drug: Campath
Age Groups: Child / Adult / Senior
First Received Date: May 21, 2008
9 Recruiting Standardization of CD3+ T Cell Dose for Patients Receiving Allogeneic Peripheral Blood Stem Cell Transplantation From Matched Related Donors
Condition: Hematopoietic Stem Cell Transplantation
Intervention: Procedure: CD3+ T cell depletion
Age Groups: Adult / Senior
First Received Date: August 12, 2009
10 Recruiting T-Cell-Depleted Allogeneic Stem Cell Transplantation After Immunoablative Induction Chemotherapy and Reduced-Intensity Transplantation Conditioning in Treating Patients With Hematologic Malignancies
Conditions: Chronic Myeloproliferative Disorders;   Leukemia;   Lymphoma;   Multiple Myeloma and Plasma Cell Neoplasm;   Myelodysplastic Syndromes;   Myelodysplastic/Myeloproliferative Diseases
Interventions: Biological: filgrastim;   Biological: graft-versus-tumor induction therapy;   Biological: rituximab;   Biological: therapeutic allogeneic lymphocytes;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: cytarabine;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: fludarabine phosphate;   Drug: prednisone;   Drug: vincristine sulfate;   Procedure: peripheral blood stem cell transplantation
Group: Adult
First Received Date: April 7, 2004
11 Recruiting T-Cell Depleted Donor Lymphocyte Infusion (DLI)for Acute Myeloid Leukemia (AML) or High Risk Myelodysplastic Syndrome (MDS)
Conditions: Acute Myeloid Leukemia;   Myelodysplastic Syndromes
Intervention: Procedure: CD8+ T-cell depleted donor lymphocyte infusion
Age Groups: Adult / Senior
First Received Date: October 19, 2005
12 Recruiting Busulfan, Melphalan, and Fludarabine With Peri-transplant Palifermin, Followed by a T-Cell Depleted Hematopoietic Stem Cell Transplant From HLA Matched or Mismatched Related or Unrelated Donors in Patients With Advanced Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)
Conditions: Acute Myeloid Leukemia;   Advanced Myelodysplastic Syndromes
Intervention: Drug: Busulfan, Melphalan, Fludarabine, Anti-Thymocyte Globulin, Palifermin, Stem cell transplant
Age Groups: Child / Adult
First Received Date: February 14, 2008
13 Recruiting Busulfan-fludarabine Conditioning and T-cell Depleted Allogeneic Stem Cell Transplantation for Patients With Advanced Hematologic Malignancies
Conditions: Leukemia;   Lymphoma;   Myeloma
Interventions: Drug: Busulfan;   Drug: Fludarabine;   Drug: Campath;   Procedure: Stem Cell Transplant
Age Groups: Adult / Senior
First Received Date: July 20, 2009
14 Recruiting In-Vitro Studies in Depletion of Haplotype Mismatched Alloreactive T Cells
Conditions: Hematologic Malignancies;   Hematopoietic Stem Cell Transplantation
Intervention: Procedure: collection of peripheral blood and apheresis samples
Age Groups: Adult / Senior
First Received Date: August 7, 2008
15 Recruiting Stem Cell Transplantation for Patients With Cancers of the Blood
Conditions: CML (Chronic Myelogenous Leukemia);   CLL (Chronic Lymphocytic Leukemia);   AML (Acute Myelogenous Leukemia);   ALL (Acute B-Lymphoblastic Leukemia);   MDS (Myelodysplastic Syndrome)
Interventions: Procedure: Peripheral Blood Stem Cell Transplant;   Device: CliniMACS and Theralux Systems
Age Groups: Adult / Senior
First Received Date: April 28, 2007
16 Recruiting Basiliximab #2: In-Vivo Activated T-Cell Depletion to Prevent Graft-Versus_Host Disease (GVHD) After Nonmyeloablative Allotransplantation for the Treatment of Blood Cancer
Conditions: Acute Myelogenous Leukemia;   Acute Lymphocytic Leukemia;   Chronic Myelogenous Leukemia;   Chronic Lymphocytic Leukemia;   Myelodysplasia;   Non-Hodgkin's Lymphoma;   Hodgkin's Disease;   Multiple Myeloma;   Myelofibrosis;   Anemia, Aplastic;   Hemoglobinuria, Paroxysmal
Intervention: Drug: Basiliximab
Age Groups: Adult / Senior
First Received Date: September 11, 2009
17 Recruiting Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease
Conditions: Chronic Myeloproliferative Disorders;   Graft Versus Host Disease;   Leukemia;   Lymphoma;   Multiple Myeloma and Plasma Cell Neoplasm;   Myelodysplastic Syndromes;   Myelodysplastic/Myeloproliferative Diseases;   Secondary Myelofibrosis;   Small Intestine Cancer
Interventions: Biological: therapeutic allogeneic lymphocytes;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: fludarabine phosphate;   Drug: tacrolimus;   Procedure: allogeneic hematopoietic stem cell transplantation;   Procedure: in vitro-treated peripheral blood stem cell transplantation;   Procedure: peripheral blood stem cell transplantation;   Radiation: total-body irradiation
Age Groups: Child / Adult / Senior
First Received Date: November 9, 2006
18 Recruiting Use of Rft5-Dga to Deplete Alloreactive Cells for Pts With Fanconi Anemia After Haploidentical SCT
Condition: Fanconi Anemia
Interventions: Procedure: CD34 selected haploidentical PBSCT;   Drug: Fludarabine;   Biological: T cell infusion;   Biological: Campath 1h;   Biological: anti-CD45
Age Groups: Child / Adult
First Received Date: December 21, 2007
19 Recruiting G-CSF PMRD: Granulocyte Colony Stimulating Factor (G-CSF) Stimulated Bone Marrow and In Vivo T-Cell Depletion in Patients With Hematologic Malignancies or Bone Marrow Failure Syndrome
Condition: Hematologic Malignancies
Intervention: Drug: Granulocyte Colony Stimulating Factor
Age Groups: Child / Adult
First Received Date: September 27, 2005
20 Recruiting Infusion of Donor Lymphocytes Depleted of CD25+ Regulatory T-Cells in Patients With Relapsed Hematologic Malignancies
Condition: Hematologic Malignancies
Intervention: Device: CliniMACS CD25 Reagent Device
Age Groups: Adult / Senior
First Received Date: May 8, 2008

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