Now Available for Public Comment: Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials
15 studies found for:    polo-like kinase
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Rank Status Study
1 Active, not recruiting Phosphoproteomic Patterns as a Novel Biomarker for Aurora and Polo-like Kinase Inhibitors in Non-Small Cell Lung Cancer
Condition: Non-Small Cell Lung Cancer
Intervention: Other: Tissue Collection
2 Recruiting A Study of CFI-400945 Fumarate in Patients With Advanced Cancer
Condition: Advanced Cancer
Intervention: Drug: CFI-400945
3 Completed Study to Assess the Pharmacokinetics and Pharmacodynamics of GSK461364 in Subjects With Non-Hodgkins Lymphoma
Conditions: Advanced Solid Tumor;   Lymphoma, Non-Hodgkin;   Non-Hodgkin's Lymphoma
Intervention: Drug: GSK461364
4 Recruiting A Study to Determine Safety, Pharmacokinetics and Pharmacodynamics of Intravenous TKM 080301 in Neuroendocrine Tumors (NET) and Adrenocortical Carcinoma (ACC) Patients
Conditions: Cancer;   Neuroendocrine Tumors;   NET;   Adrenocortical Carcinoma;   ACC
Intervention: Drug: TKM-080301
5 Completed Study of NMS-1286937 in Adult Patients With Advanced/Metastatic Solid Tumors
Condition: Advanced or Metastatic Solid Tumors
Intervention: Drug: NMS-1286937
6 Terminated
Has Results
Study of Orally Administered TAK-960 in Patients With Advanced Nonhematologic Malignancies
Condition: Advanced Nonhematological Malignancies
Intervention: Drug: TAK-960
7 Completed BI 6727 (Volasertib) Randomised Trial in Ovarian Cancer
Condition: Ovarian Neoplasms
Interventions: Drug: Paclitaxel;   Drug: Gemcitabine;   Drug: Topotecan;   Drug: Pegylated liposomal doxorubicin (PLD);   Drug: BI 6727
8 Recruiting Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Intravenous TKM-080301 in Subjects With Advanced Hepatocellular Carcinoma
Conditions: Hepatocellular Carcinoma;   Hepatoma;   Liver Cancer, Adult;   Liver Cell Carcinoma, Adult
Intervention: Drug: TKM-080301
9 Completed Open, Randomized Phase II Trial to Investigate the Efficacy and Safety of the PLK-1 Inhibitor BI 2536 in Patients With Advanced, Unresectable Pancreatic Cancer
Condition: Pancreatic Neoplasms
Intervention: Drug: BI 2536
10 Completed TKM 080301 for Primary or Secondary Liver Cancer
Conditions: Colorectal Cancer With Hepatic Metastases;   Pancreas Cancer With Hepatic Metastase;   Gastric Cancer With Hepatic Metastase;   Breast Cancer With Hepatic Metastase;   Ovarian Cancer With Hepatic Metastase
Intervention: Drug: TKM-080301
11 Completed BI 6727 (Volasertib) Monotherapy Phase I Trial in Japanese Patients With Advanced Solid Tumours
Condition: Neoplasms
Interventions: Drug: Volasertib, low dose, d1q3w;   Drug: Volasertib, middle dose, d1q3w;   Drug: Volasertib, high dose, d1q3w
12 Completed BI 6727 (Volasertib) Human ADME Trial in Various Solid Tumours
Condition: Neoplasms
Intervention: Drug: BI 6727
13 Unknown  Tarceva Italian Lung Optimization tRial
Condition: Non Small Cell Lung Cancer (NSCLC)
Interventions: Drug: Erlotinib;   Drug: Docetaxel
14 Completed TORCH: A Study of Tarceva or Chemotherapy for the Treatment of Advanced Non Small Cell Lung Cancer
Condition: Advanced Non-Small Cell Lung Cancer
Interventions: Drug: erlotinib;   Drug: cisplatin;   Drug: gemcitabine
15 Completed STI 571 (GLIVEC) in the Treatment of Adult Acute Lymphoblastic Leukemia
Condition: Acute Lymphoblastic Leukemia
Intervention: Drug: Imatinib

Indicates status has not been verified in more than two years