15 studies found for:    mGluR1
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Rank Status Study
1 Recruiting PET Imaging of Brain mGluR1 Receptors Using [18F]FIMX
Conditions: Anxiety Disorder;   Major Depressive Disorder
2 Withdrawn Riluzole in Women With Stage I, Stage II, or Stage IIIA Breast Cancer
Condition: Breast Cancer
Interventions: Drug: riluzole;   Genetic: polymorphism analysis;   Procedure: axillary lymph node biopsy;   Procedure: digital image analysis;   Procedure: needle biopsy;   Procedure: sentinel lymph node biopsy;   Procedure: therapeutic conventional surgery
3 Terminated Imaging of Brain Receptors Using (11C)mGlu1
Conditions: Dosimetry;   Pharmacokinetics
Intervention: Drug: [11C]LY2428703
4 Completed An Open Label Positron Emission Tomography (PET) Study to Determine Central mGluR5 Receptor Occupancy of AZD2516
Condition: Healthy
Intervention: Drug: AZD2516
5 Completed Positron Emission Tomography (PET) Study With [11C]AZ12713580 to Determine Central mGluR5 Receptor Occupancy of AZD2066
Condition: Healthy
Interventions: Drug: AZD2066;   Drug: radioligand [11C] AZ12713580
6 Recruiting Evaluation of Two Radioactive Chemicals to Image mGluR5 Receptors in Brain
Condition: mGluR5 Receptors
Intervention: Drug: STX107
7 Completed A Study of BCI-838 and Several BCI-632 Prodrugs in Healthy Volunteers
Condition: Healthy
Interventions: Drug: BCI-838;   Drug: BCI-1038, BCI-1206 & BCI-1283
8 Completed A Multiple Ascending Dose Study of BCI-838 in Healthy Volunteers
Condition: Healthy
Intervention: Drug: BCI-838
9 Recruiting A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions
Conditions: Parkinson Disease;   Huntington Disease;   Autistic Spectrum Disorders;   Fragile X Syndrome;   Alzheimer Disease;   Mild Cognitive Impairment
Intervention: Drug: [18F]FPEB
10 Completed The Effects AZD8529 on Ketamine-induced Impairment of Working Memory in Healthy Volunteers
Conditions: Healthy;   Memory Impairment
Interventions: Drug: AZD8529;   Drug: Placebo to match AZD8529
11 Recruiting PET Imaging of mGLuR5 With Drug Challenge
Conditions: Major Depressive Disorder;   Post-Traumatic Stress Disorder (PTSD)
12 Completed Acamprosate: Genes Associated With Response
Condition: Alcoholism
Intervention: Drug: acamprosate
13 Terminated ADX10059 Migraine Prevention Study
Condition: Migraine
Interventions: Drug: ADX10059;   Drug: ADX10059 Matching Placebo
14 Recruiting Study to Evaluate the Effect of AFQ056 in Obsessive Compulsive Disorder (OCD) Patients Resistant to Selective Serotonin Reuptake Inhibitor (SSRI) Therapy
Conditions: Patient Diagnosed With OCD;   and Resistant to SSRI Treatment (Failed SSRI Over 12 Weeks at Appropriate Doses).
Interventions: Drug: AFQ056;   Drug: Placebo
15 Not yet recruiting Biomarker Assessment of Glutamatergic Target Engagement
Condition: Healthy Controls
Interventions: Drug: Ketamine;   Drug: Normal saline

Indicates status has not been verified in more than two years