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58 studies found for:    kuvan

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Rank Status Study
21 Completed Tetrahydrobiopterin Treatment in Children With Idiopathic Cognitive Developmental Disorders
Condition: Children With Idiopathic Cognitive Developmental Disorders
Intervention: Drug: sapropterin dihydrochloride
22 Completed Effects of Tetrahydrobiopterin on Blood Pressure
Condition: Hypertension
Intervention: Drug: Tetrahydrobiopterin
23 Withdrawn Trial of Kuvan in Lesch-Nyhan Disease
Condition: Behavioral Manifestations of Lesch-Nyhan Disease
Intervention: Drug: sapropterin
24 Completed A Study of the Effects of 6R-BH4 on Blood Pressure in Subjects With Poorly Controlled Systemic Hypertension
Condition: Hypertension
Intervention: Drug: 6R-BH4 (sapropterin dihydrochloride)
25 Enrolling by invitation Bone Mineral Density in Adults With Hyperphenylalaninemia on Kuvan Therapy
Conditions: Hyperphenylalaninemia;   Phenylketonuria
Intervention: Drug: Sapropterin
26 Completed A Phase 1 Study to Evaluate Effects of Sapropterin Dihydrochloride on QTc Intervals in Healthy Adult Subjects
Condition: Phenylketonuria
Intervention: Drug: sapropterin dihydrochloride
27 Terminated Long-Term Tetrahydrobiopterin Treatment in PKU Patients of 0-18 Years - Study on Phenylalanine Tolerance and Safety
Condition: Phenylalanine Hydroxylase Deficiencies
Intervention: Drug: tetrahydrobiopterin (BH4)
28 Unknown † Response to Phenylketonuria to Tetrahydrobiopterin (BH4)
Condition: Phenylketonuria
Intervention: Drug: tetrahydrobiopterin (BH4)
29 Unknown † Effect of 6R-BH4 Treatment in Coronary Artery Disease (OXBIO Study)
Condition: Coronary Artery Disease
Intervention: Drug: 6R-BH4
30 Completed Safety and Efficacy Study of Phenoptin in Subjects With Hyperphenylalaninemia Due to BH4 Deficiency
Conditions: Tetrahydrobiopterin Deficiencies;   Hyperphenylalaninemia, Non-Phenylketonuric
Intervention: Drug: Phenoptin
31 Unknown † Sapropterin as a Treatment for Autistic Disorder
Condition: Autistic Disorder
Interventions: Drug: sapropterin;   Drug: Placebo
32 Unknown † The Purpose of This Pilot Study is to Assess the Impact of KUVAN® (Sapropterin Dihydrochloride) on Gastric Relaxation in Women With Diabetic Gastroparesis.
Condition: Gastroparesis
Intervention: Drug: sapropterin dihydrochloride
33 Unknown † Nutritional and Neurotransmitter Changes in PKU Subjects on BH4
Condition: Phenylketonuria
Intervention:
34 Recruiting Neuroimaging and Neurocognitive Assessment and Response to Sapropterin Dihydrochloride Treatment in Phenylketonuria
Condition: PKU
Interventions: Dietary Supplement: diet;   Drug: sapropterin dihydrochloride
35 Recruiting Endothelial Facilitation in Alzheimer's Disease
Condition: Alzheimer's Disease
Intervention: Drug: Simvastatin + L-Arginine + Tetrahydrobiopterin
36 Completed Study to Evaluate the Response to and Safety of an 8-Day Course of Phenoptin™ Treatment in Subjects With Phenylketonuria
Condition: Phenylketonurias
Intervention: Drug: sapropterin dihydrochloride
37 Completed Study of BH4, a New and Simple Treatment of Mild PKU
Condition: Phenylketonuria
Intervention: Drug: 5,6,7,8-tetrahydrobiopterin
38 Unknown † 6R-BH4 Pulmonary Arterial Hypertension Study
Condition: Pulmonary Arterial Hypertension
Intervention: Drug: sapropterin dihydrochloride (6R-BH4)
39 Active, not recruiting Tetrahydrobiopterin in Patients With Chronic Kidney Disease (CKD) and Albuminuria
Conditions: Kidney Disease;   Albuminuria
Interventions: Drug: Tetrahydrobiopterin (6R BH4);   Dietary Supplement: Vitamin C
40 Completed A Phase 3, Multicenter, Open-Label Extension Study of Phenoptin in Subjects With PKU Who Have Elevated Phenylalanine Levels
Condition: Phenylketonurias
Intervention: Drug: sapropterin dihydrochloride
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† Indicates status has not been verified in more than two years