90 studies found for:    kuvan
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Rank Status Study
21 Suspended Kuvan in People With Schizophrenia and Schizoaffective Disorder
Conditions: Schizophrenia;   Schizoaffective Disorder
Interventions: Drug: Kuvan;   Drug: Multivitamin
22 Recruiting Sapropterin on Cognitive Abilities in Young Adults With Phenylketonuria
Condition: Phenylketonuria
Interventions: Drug: Sapropterin;   Drug: Placebo
23 Completed Effects of Tetrahydrobiopterin on Blood Pressure
Condition: Hypertension
Intervention: Drug: Tetrahydrobiopterin
24 Enrolling by invitation Bone Mineral Density in Adults With Hyperphenylalaninemia on Kuvan Therapy
Conditions: Hyperphenylalaninemia;   Phenylketonuria
Intervention: Drug: Sapropterin
25 Terminated Neuroimaging and Neurocognitive Assessment and Response to Sapropterin Dihydrochloride Treatment in Phenylketonuria
Condition: PKU
Interventions: Dietary Supplement: diet;   Drug: sapropterin dihydrochloride
26 Completed
Has Results
Tetrahydrobiopterin Treatment in Children With Idiopathic Cognitive Developmental Disorders
Condition: Autism Spectrum Disorder
Intervention: Drug: sapropterin dihydrochloride
27 Completed
Has Results
Sapropterin as a Treatment for Autistic Disorder
Condition: Autistic Disorder
Interventions: Drug: sapropterin;   Drug: Placebo
28 Unknown  Effect of 6R-BH4 Treatment in Coronary Artery Disease (OXBIO Study)
Condition: Coronary Artery Disease
Intervention: Drug: 6R-BH4
29 Completed
Has Results
Nutritional and Neurotransmitter Changes in PKU Subjects on BH4
Condition: Phenylketonuria
Intervention: Drug: KuvanTM Therapy
30 Completed A Study of the Effects of 6R-BH4 on Blood Pressure in Subjects With Poorly Controlled Systemic Hypertension
Condition: Hypertension
Intervention: Drug: 6R-BH4 (sapropterin dihydrochloride)
31 Withdrawn Trial of Kuvan in Lesch-Nyhan Disease
Condition: Behavioral Manifestations of Lesch-Nyhan Disease
Intervention: Drug: sapropterin
32 Recruiting Observational Study on the Long Term Safety of Kuvan® Treatment in Patients With Hyperphenylalaninemia (HPA) Due to Phenylketonuria (PKU) or BH4 Deficiency
Condition: Hyperphenylalaninemia (HPA) Due to Phenylketonuria (PKU) or Tetrahydrobiopterin (BH4) Deficiency
Intervention:
33 Completed Study of BH4, a New and Simple Treatment of Mild PKU
Condition: Phenylketonuria
Intervention: Drug: 5,6,7,8-tetrahydrobiopterin
34 Unknown  Oral 6R-BH4 for the Treatment of Isolated Systolic Hypertension and Endothelial Dysfunction
Conditions: Isolated Systolic Hypertension;   Endothelial Dysfunction
Interventions: Drug: 6R-BH4;   Other: Placebo
35 Terminated Long-Term Tetrahydrobiopterin Treatment in PKU Patients of 0-18 Years - Study on Phenylalanine Tolerance and Safety
Condition: Phenylalanine Hydroxylase Deficiencies
Intervention: Drug: tetrahydrobiopterin (BH4)
36 Approved for marketing Sapropterin Expanded Access Program
Condition: Phenylketonuria
Intervention: Drug: Sapropterin dihydrochloride
37 Completed 6R-BH4 Pulmonary Arterial Hypertension Study
Condition: Pulmonary Arterial Hypertension
Intervention: Drug: sapropterin dihydrochloride (6R-BH4)
38 Completed Randomized Controlled Trial to Assess the Effects of Sapropterin on Hepatic and Systemic Hemodynamics in Patients With Liver Cirrhosis and Portal Hypertension
Conditions: Liver Cirrhosis;   Portal Hypertension
Intervention: Drug: sapropterin
39 Recruiting Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
Conditions: Menopause;   Aging;   Vascular Health
Interventions: Drug: KUVAN;   Drug: Placebo;   Drug: Cetrotide;   Drug: Climara;   Drug: Placebo transdermal patch
40 Unknown  Response to Phenylketonuria to Tetrahydrobiopterin (BH4)
Condition: Phenylketonuria
Intervention: Drug: tetrahydrobiopterin (BH4)

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Indicates status has not been verified in more than two years