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Found 57 studies with search of: brca2
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1 Completed Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer
Interventions: Genetic: DNA analysis;   Genetic: mutation analysis;   Genetic: polymorphism analysis;   Other: laboratory biomarker analysis;   Procedure: evaluation of cancer risk factors
2 Recruiting Studying Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer
Interventions: Genetic: DNA analysis;   Genetic: mutation analysis;   Genetic: polymorphism analysis;   Other: laboratory biomarker analysis;   Procedure: evaluation of cancer risk factors
3 Terminated Study of Mitomycin-C in Patients With Advanced or Recurrent Pancreatic Cancer With Mutated BRCA2 Gene
Condition: Pancreatic Cancer
Intervention: Drug: Mitomycin C
4 Recruiting AZD2281 and Carboplatin in Treating Patients With BRCA1/BRCA2-Associated, Hereditary, or Triple Negative Metastatic or Unresectable Breast Cancer or Ovarian Epithelial Cancer
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer;   Hereditary Breast/Ovarian Cancer (brca1, brca2);   Ovarian Cancer
Interventions: Drug: carboplatin;   Drug: olaparib;   Genetic: polymorphism analysis;   Other: enzyme-linked immunosorbent assay;   Other: laboratory biomarker analysis;   Other: pharmacogenomic studies
5 Recruiting Letrozole in Preventing Breast Cancer in Postmenopausal Women With a BRCA1 or BRCA2 Mutation
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer;   Hereditary Breast/Ovarian Cancer (brca1, brca2)
Interventions: Drug: letrozole;   Other: laboratory biomarker analysis;   Other: pharmacogenomic studies
6 Recruiting Impact of Testing Positive for the BRCA1 or BRCA2 Mutation in Young Women Who Are BRCA1 or BRCA2 Mutation Carriers
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Sexuality and Reproductive Issues
Interventions: Behavioral: telephone-based intervention;   Other: questionnaire administration;   Procedure: psychosocial assessment and care
7 Active, not recruiting Germline BRCA1 and BRCA2 Mutations in Jewish Women Affected by Breast Cancer
Condition: Breast Cancer
Interventions: Other: Blood test;   Other: Questionnaire
8 Recruiting National Screening in Denmark With MR Versus Mammography and Ultrasound of Women With BRCA1 or BRCA2 Mutations
Condition: Breast Cancer
Interventions: Procedure: MR mammography;   Procedure: MR
9 Active, not recruiting Imaging Procedures in Women With a Genetic Risk For Breast Cancer
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer;   Hereditary Breast/Ovarian Cancer (brca1, brca2)
Interventions: Genetic: cytogenetic analysis;   Other: cytology specimen collection procedure;   Procedure: breast duct lavage;   Procedure: breast imaging study;   Procedure: magnetic resonance imaging;   Procedure: mutation carrier screening;   Procedure: positron emission tomography;   Procedure: radiomammography;   Procedure: ultrasound imaging
10 Active, not recruiting Single Arm Study of BSI-201 in Patients With BRCA-1 or BRCA-2 Associated Advanced Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Conditions: Primary Peritoneal Cancer;   Advanced Epithelial Ovarian Cancer
Intervention: Drug: BSI-201
11 Recruiting Establishing the Incidences of BRCA1 and BRCA2 Mutation by Combining DHPLC and Direct Sequencing in Ovarian Cancer
Condition: Ovarian Cancer
Intervention:
12 Recruiting Telephone-Based Genetic Counseling or Standard Genetic Counseling in Women at Risk of Carrying the BRCA1 or BRCA2 Mutation
Condition: Breast Cancer
Interventions: Genetic: mutation analysis;   Other: counseling intervention
13 Active, not recruiting Genetic Counseling in Women at Risk for BRCA1 or BRCA2 Mutations
Condition: Breast Cancer
Intervention: Other: counseling intervention
14 Recruiting AG014699 in Treating Patients With Locally Advanced or Metastatic Breast Cancer or Advanced Ovarian Cancer
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer;   Ovarian Cancer
Interventions: Drug: PARP-1 inhibitor AG014699;   Genetic: protein expression analysis;   Genetic: western blotting;   Other: immunohistochemistry staining method;   Other: liquid chromatography;   Other: mass spectrometry;   Other: pharmacological study
15 Recruiting ABT-888, Carboplatin, and Paclitaxel in Treating Patients With Advanced Solid Cancer
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Hereditary Breast/Ovarian Cancer (brca1, brca2);   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: ABT-888;   Drug: carboplatin;   Drug: paclitaxel
16 Recruiting Carboplatin or Docetaxel in Treating Women With Metastatic Genetic Breast Cancer
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer;   Hereditary Breast/Ovarian Cancer (brca1, brca2)
Interventions: Drug: carboplatin;   Drug: docetaxel
17 Recruiting ABT-888 in Treating Patients With Malignant Solid Tumors That Did Not Respond to Previous Therapy
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer;   Fallopian Tube Cancer;   Hereditary Breast/Ovarian Cancer (brca1, brca2);   Ovarian Cancer;   Pancreatic Cancer;   Peritoneal Cavity Cancer;   Prostate Cancer;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: ABT-888;   Other: laboratory biomarker analysis;   Other: liquid chromatography;   Other: mass spectrometry;   Other: pharmacological study
18 Recruiting The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer
Condition: Prostate Cancer in BRCA1 and BRCA2 Carriers
Interventions: Behavioral: PSA test;   Procedure: Prostate Biopsy (only if raised PSA level)
19 Completed Study to Assess the Efficacy and Safety of a PARP Inhibitor for the Treatment of BRCA-Positive Advanced Breast Cancer
Condition: Breast Neoplasms
Intervention: Drug: KU-0059436 (AZD2281)(PARP inhibitor)
20 Completed Study to Assess the Efficacy and Safety of a PARP Inhibitor for the Treatment of BRCA-Positive Advanced Ovarian Cancer
Condition: Ovarian Neoplasm
Intervention: Drug: KU-0059436 (AZD2281)(PARP inhibitor)

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