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97 studies found for:    TP53
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Rank Status Study
1 Recruiting Clinical and Genetic Studies of Li-Fraumeni Syndrome
Conditions: Li-Fraumeni Syndrome;   Neoplasms;   Tp53 Mutations
Intervention:
2 Unknown  Magnetic Resonance Imaging Screening in Li Fraumeni Syndrome
Condition: Li-Fraumeni Syndrome
Interventions: Other: Whole body MRI;   Other: Psychological questionnaires
3 Unknown  rAd-p53 Gene Therapy for Advanced Oral and Maxillofacial Malignant Tumors
Condition: Advanced Oral and Maxillofacial Malignant Tumors
Interventions: Drug: p53 gene with surgery;   Procedure: surgery;   Drug: p53 with chemotherapy;   Drug: p53 gene therapy
4 Recruiting A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome
Condition: Li-Fraumeni Syndrome
Intervention: Drug: Metformin
5 Unknown  rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors
Condition: Advanced Malignant Thyroid Tumors
Interventions: Drug: rAd-p53 gene;   Procedure: surgery;   Drug: p53 gene therapy;   Radiation: p53 gene therapy with radioactive iodine
6 Recruiting Study to Determine and Evaluate a Safe and Tolerated Dose of HDM201 in Patients With Selected Advanced Tumors That Are TP53wt
Condition: Advanced Solid and Hematological TP53wt Tumors
Intervention: Drug: HDM201
7 Not yet recruiting Surgery Combined With rAd-p53 Gene in Treatment Advanced Non-small-cell Carcinoma
Condition: Non-small Cell Lung Cancer
Interventions: Drug: Surgery combined with rAd-p53 gene therapy;   Procedure: Surgery
8 Active, not recruiting Biomarker Monitoring in TP53 Mutation Carriers
Conditions: Li-Fraumeni Syndrome;   Hereditary Cancer Syndromes;   TP53 Gene Inactivation
Intervention:
9 Recruiting Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome
Condition: Li-Fraumeni Syndrome
Intervention:
10 Completed Gene Therapy in Preventing Cancer in Patients With Premalignant Carcinoma of the Oral Cavity or Pharynx
Conditions: Lip and Oral Cavity Cancer;   Oropharyngeal Cancer;   Stage 0 Lip and Oral Cavity Cancer;   Stage 0 Oropharyngeal Cancer;   Tongue Cancer
Interventions: Biological: Ad5CMV-p53 gene;   Other: laboratory biomarker analysis
11 Recruiting p53 and Response to Preoperative Radiotherapy for T2 and T3
Condition: Rectal Cancer
Intervention: Radiation: preoperative short course radiation
12 Recruiting LIFSCREEN : Evaluation of Whole Body MRI for Early Detection of Cancers in Subjects With P53 Mutation (Li-Fraumeni Syndrome)
Condition: Li Fraumeni Syndrome
Intervention: Other: whole body MRI
13 Not yet recruiting A Phase II Study Comparing AZD1775 + Chemotherapy Versus Chemotherapy Alone in Patients to Treat Ovarian, Fallopian Tube, or Primary Peritoneal Cancer.
Condition: Platinum-resistant TP53-mutated Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Intervention: Drug: AZD1775
14 Unknown  p53 Gene Therapy for Head and Neck Malignant Tumors in Advanced Stage
Condition: Neoplasms
Interventions: Drug: chemotherapy plus p53;   Drug: chemotherapy;   Radiation: radiotherapy
15 Unknown  Gene Therapy in Treating Patients With Advanced Recurrent or Persistent Ovarian Cancer or Primary Peritoneal Cancer
Conditions: Ovarian Cancer;   Peritoneal Cavity Cancer
Intervention: Biological: Ad5CMV-p53 gene
16 Terminated Wild Type p53 Adenovirus for Oral Premalignancies
Condition: Mouth Cancer
Intervention: Genetic: INGN 201
17 Completed Gene Therapy Plus Chemotherapy in Treating Patients With Breast Cancer
Condition: Breast Cancer
Interventions: Biological: Ad5CMV-p53 gene;   Drug: chemotherapy
18 Completed Gene Therapy in Treating Patients With Recurrent Malignant Gliomas
Condition: Brain and Central Nervous System Tumors
Interventions: Biological: Ad5CMV-p53 gene;   Procedure: conventional surgery
19 Completed Genetic Polymorphisms Associated With Cigarette Smoking and Risk of Graves’ Disease
Condition: Graves' Disease
Intervention:
20 Terminated Gene Therapy in Treating Patients With Cancer of The Liver
Condition: Liver Cancer
Intervention: Biological: Ad5CMV-p53 gene

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Indicates status has not been verified in more than two years