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27 studies found for:    SLCO1B1
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Rank Status Study
1 Completed Influence of Organic Anion Transporting Polypeptide1B1(OATP1B1) Genotype on Rosuvastatin PK, PD and Lipid Profiles
Conditions: Organic Anion Transporting Polypeptide1B1 (OATP1B1);   Rosuvastatin
Intervention: Drug: Rosuvastatin
2 Recruiting Genetically Guided Statin Therapy
Conditions: Hypercholesterolemia;   HMG COA Reductase Inhibitor Adverse Reaction
Interventions: Genetic: Reporting for SLCO1B1*5 allele at randomization;   Genetic: Reporting for SLCO1B1*5 allele at the end;   Genetic: Genetic testing for SLCO1B1*5 allele
3 Unknown  Study of Genetic Polymorphisms of Drug Transporters and Orphan Nuclear Receptors on Treatment Effects of Irinotecan
Conditions: Colorectal Neoplasms;   Secondary
Intervention: Drug: irinotecan
4 Completed
Has Results
Genetic Predictors of Variability in the Drug-drug Interaction Between Darunavir/Ritonavir and Pravastatin
Conditions: HIV Infections;   Hyperlipidemia
Interventions: Drug: Pravastatin;   Drug: Darunavir;   Drug: Ritonavir;   Other: Washout
5 Completed Influence of OATP1B1 and BRCP Genotype on Rosuvastatin PK, PD and Lipidomics in Hyperlipidemic Patients
Condition: Hypercholesterolemia
Intervention: Drug: Rosuvastatin
6 Completed Influence of the OATP1B1 and OATP1B3 Genotype on the Hepatic Uptake of Primovist®
Conditions: Pharmacokinetics;   MRI;   Liver;   Drug Transporter;   Gd-EOB-DTPA
Interventions: Drug: Primovist® 0,25 mmol/ml solution for injection;   Device: MRI
7 Active, not recruiting Statin Therapy to Improve Medication Adherence
Conditions: Hypercholesterolemia;   HMG COA Reductase Inhibitor Adverse Reaction
Intervention: Genetic: Genetic testing and reporting for SLCO1B1*5 allele
8 Completed A Study to Investigate the Effect of GSK1605786 on Hepatic Cytochrome P450, and BCRP and OATP1B1 Transport in Healthy Adult Subjects
Condition: Crohn's Disease
Intervention: Drug: GSK1605786
9 Completed Influence of OATP1B1 and CYP2C9 Genotypes on the Pharmacokinetics of Steady State Bosentan Before and During CYP3A4-inhibition by Clarithromycin
Conditions: Drug Interaction;   Steady-state;   Bosentan
Intervention:
10 Unknown  Effect of Genes on Rosuvastatin Therapy for Hyperlipidemia
Condition: Hyperlipidemia
Interventions: Drug: rosuvastatin,fenofibrate;   Genetic: CYP2C9, UGT1A1, UGT1A3, OATP2, BCRP
11 Completed Drug Interaction Between Colchicine and Calcineurin Inhibitors in Renal Graft Recipients
Condition: Renal Replacement Therapies
Interventions: Drug: cyclosporine+colchicine;   Drug: tacrolimus
12 Recruiting Pharmacokinetics of Anti-TB Drugs in HIV/TB Co-infected Children in Ghana
Conditions: Tuberculosis;   HIV
Intervention:
13 Completed Validation Study of Multiple Probe Compounds for Drug Interaction Evaluation
Condition: Drug Interactions
Interventions: Drug: Caffeine;   Drug: Rosiglitazone;   Drug: Flurbiprofen;   Drug: Omeprazole;   Drug: Dextromethorphan;   Drug: Midazolam;   Drug: Rosuvastatin;   Drug: Ketoconazole;   Drug: Fluconazole;   Drug: Rifampin
14 Completed Drug-Drug Interaction Study With PF-05089771
Condition: Healthy
Intervention: Drug: Pravastatin, midazolam, losartan, omeprazole, caffeine and PF-05089771
15 Completed Evaluating the Pharmacokinetics of High-Dose Rifapentine When Given as a Single Dose or in Divided Doses to Healthy Adults
Condition: Tuberculosis
Intervention: Drug: Rifapentine (RPT)
16 Completed A Study to Investigate the Effects of Rifampicin on the Pharmacokinetics of Aleglitazar in Healthy Volunteers
Condition: Healthy Volunteer
Interventions: Drug: aleglitazar;   Drug: rifampicin
17 Not yet recruiting Effects of Dabrafenib on the Single Dose Pharmacokinetics (PK) of Rosuvastatin and Midazolam
Condition: Cancer
Interventions: Drug: Rosuvastatin10 mg tablet;   Drug: Midazolam 3 mg syrup;   Drug: Dabrafenib 75 mg capsule
18 Active, not recruiting AR-42 in Treating Patients With Advanced or Relapsed Multiple Myeloma, Chronic Lymphocytic Leukemia, or Lymphoma
Conditions: Adult Nasal Type Extranodal NK/T-cell Lymphoma;   Anaplastic Large Cell Lymphoma;   Angioimmunoblastic T-cell Lymphoma;   Cutaneous B-cell Non-Hodgkin Lymphoma;   Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue;   Hepatosplenic T-cell Lymphoma;   Intraocular Lymphoma;   Nodal Marginal Zone B-cell Lymphoma;   Peripheral T-cell Lymphoma;   Post-transplant Lymphoproliferative Disorder;   Prolymphocytic Leukemia;   Recurrent Adult Burkitt Lymphoma;   Recurrent Adult Diffuse Large Cell Lymphoma;   Recurrent Adult Diffuse Mixed Cell Lymphoma;   Recurrent Adult Diffuse Small Cleaved Cell Lymphoma;   Recurrent Adult Grade III Lymphomatoid Granulomatosis;   Recurrent Adult Hodgkin Lymphoma;   Recurrent Adult Immunoblastic Large Cell Lymphoma;   Recurrent Adult Lymphoblastic Lymphoma;   Recurrent Adult T-cell Leukemia/Lymphoma;   Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma;   Recurrent Grade 1 Follicular Lymphoma;   Recurrent Grade 2 Follicular Lymphoma;   Recurrent Grade 3 Follicular Lymphoma;   Recurrent Mantle Cell Lymphoma;   Recurrent Marginal Zone Lymphoma;   Recurrent Mycosis Fungoides/Sezary Syndrome;   Recurrent Small Lymphocytic Lymphoma;   Refractory Chronic Lymphocytic Leukemia;   Refractory Multiple Myeloma;   Stage III Adult Burkitt Lymphoma;   Stage III Adult Diffuse Large Cell Lymphoma;   Stage III Adult Diffuse Mixed Cell Lymphoma;   Stage III Adult Diffuse Small Cleaved Cell Lymphoma;   Stage III Adult Hodgkin Lymphoma;   Stage III Adult Immunoblastic Large Cell Lymphoma;   Stage III Adult Lymphoblastic Lymphoma;   Stage III Adult T-cell Leukemia/Lymphoma;   Stage III Chronic Lymphocytic Leukemia;   Stage III Cutaneous T-cell Non-Hodgkin Lymphoma;   Stage III Grade 1 Follicular Lymphoma;   Stage III Grade 2 Follicular Lymphoma;   Stage III Grade 3 Follicular Lymphoma;   Stage III Mantle Cell Lymphoma;   Stage III Marginal Zone Lymphoma;   Stage III Multiple Myeloma;   Stage III Mycosis Fungoides/Sezary Syndrome;   Stage III Small Lymphocytic Lymphoma;   Stage IV Adult Burkitt Lymphoma;   Stage IV Adult Diffuse Large Cell Lymphoma;   Stage IV Adult Diffuse Mixed Cell Lymphoma;   Stage IV Adult Diffuse Small Cleaved Cell Lymphoma;   Stage IV Adult Hodgkin Lymphoma;   Stage IV Adult Immunoblastic Large Cell Lymphoma;   Stage IV Adult Lymphoblastic Lymphoma;   Stage IV Adult T-cell Leukemia/Lymphoma;   Stage IV Chronic Lymphocytic Leukemia;   Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma;   Stage IV Grade 1 Follicular Lymphoma;   Stage IV Grade 2 Follicular Lymphoma;   Stage IV Grade 3 Follicular Lymphoma;   Stage IV Mantle Cell Lymphoma;   Stage IV Marginal Zone Lymphoma;   Stage IV Mycosis Fungoides/Sezary Syndrome;   Stage IV Small Lymphocytic Lymphoma;   Testicular Lymphoma;   Waldenstrom Macroglobulinemia
Interventions: Other: Pharmacodynamic Studies;   Other: Fatigue Inventory;   Other: Pharmacogenomic studies;   Drug: AR-42
19 Completed Investigations on the Influence of Bariatric Surgery on the Metabolism and Absorption of Atorvastatin
Condition: Morbid Obesity
Intervention: Procedure: Bariatric surgery
20 Completed The Rosuvastatin In TrAnsplant Recipients Study
Conditions: Disorder Related to Renal Transplantation;   Hypercholesterolemia
Intervention: Drug: Rosuvastatin

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