22 studies found for:    SLCO1B1
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Rank Status Study
1 Completed Influence of Organic Anion Transporting Polypeptide1B1(OATP1B1) Genotype on Rosuvastatin PK, PD and Lipid Profiles
Conditions: Organic Anion Transporting Polypeptide1B1 (OATP1B1);   Rosuvastatin
Intervention: Drug: Rosuvastatin
2 Recruiting Genetically Guided Statin Therapy
Conditions: Hypercholesterolemia;   HMG COA Reductase Inhibitor Adverse Reaction
Interventions: Genetic: Reporting for SLCO1B1*5 allele at randomization;   Genetic: Reporting for SLCO1B1*5 allele at the end;   Genetic: Genetic testing for SLCO1B1*5 allele
3 Completed Influence of OATP1B1 and BRCP Genotype on Rosuvastatin PK, PD and Lipidomics in Hyperlipidemic Patients
Condition: Hypercholesterolemia
Intervention: Drug: Rosuvastatin
4 Unknown  Study of Genetic Polymorphisms of Drug Transporters and Orphan Nuclear Receptors on Treatment Effects of Irinotecan
Conditions: Colorectal Neoplasms;   Secondary
Intervention: Drug: irinotecan
5 Completed
Has Results
Genetic Predictors of Variability in the Drug-drug Interaction Between Darunavir/Ritonavir and Pravastatin
Conditions: HIV Infections;   Hyperlipidemia
Interventions: Drug: Pravastatin;   Drug: Darunavir;   Drug: Ritonavir;   Other: Washout
6 Completed Influence of the OATP1B1 and OATP1B3 Genotype on the Hepatic Uptake of Primovist®
Conditions: Pharmacokinetics;   MRI;   Liver;   Drug Transporter;   Gd-EOB-DTPA
Interventions: Drug: Primovist® 0,25 mmol/ml solution for injection;   Device: MRI
7 Completed A Study to Investigate the Effect of GSK1605786 on Hepatic Cytochrome P450, and BCRP and OATP1B1 Transport in Healthy Adult Subjects
Condition: Crohn's Disease
Intervention: Drug: GSK1605786
8 Completed Influence of OATP1B1 and CYP2C9 Genotypes on the Pharmacokinetics of Steady State Bosentan Before and During CYP3A4-inhibition by Clarithromycin
Conditions: Drug Interaction;   Steady-state;   Bosentan
Intervention:
9 Active, not recruiting Statin Therapy to Improve Medication Adherence
Conditions: Hypercholesterolemia;   HMG COA Reductase Inhibitor Adverse Reaction
Intervention: Genetic: Genetic testing and reporting for SLCO1B1*5 allele
10 Available Effect of Genes on Rosuvastatin Therapy for Hyperlipidemia
Condition: Hyperlipidemia
Interventions: Drug: rosuvastatin,fenofibrate;   Genetic: CYP2C9, UGT1A1, UGT1A3, OATP2, BCRP
11 Completed Validation Study of Multiple Probe Compounds for Drug Interaction Evaluation
Condition: Drug Interactions
Interventions: Drug: Caffeine;   Drug: Rosiglitazone;   Drug: Flurbiprofen;   Drug: Omeprazole;   Drug: Dextromethorphan;   Drug: Midazolam;   Drug: Rosuvastatin;   Drug: Ketoconazole;   Drug: Fluconazole;   Drug: Rifampin
12 Recruiting Pharmacokinetics of Anti-TB Drugs in HIV/TB Co-infected Children in Ghana
Conditions: Tuberculosis;   HIV
Intervention:
13 Completed Drug Interaction Between Colchicine and Calcineurin Inhibitors in Renal Graft Recipients
Condition: Renal Replacement Therapies
Interventions: Drug: cyclosporine+colchicine;   Drug: tacrolimus
14 Completed Renal and Hepatic Clearance Following High-Dose Methotrexate in Childhood ALL
Condition: Lymphoblastic Leukemia, Acute, Childhood
Intervention:
15 Completed Drug-Drug Interaction Study With PF-05089771
Condition: Healthy
Intervention: Drug: Pravastatin, midazolam, losartan, omeprazole, caffeine and PF-05089771
16 Completed A Study to Investigate the Effects of Rifampicin on the Pharmacokinetics of Aleglitazar in Healthy Volunteers
Condition: Healthy Volunteer
Interventions: Drug: aleglitazar;   Drug: rifampicin
17 Not yet recruiting Effects of Dabrafenib on the Single Dose Pharmacokinetics (PK) of Rosuvastatin and Midazolam
Condition: Cancer
Interventions: Drug: Rosuvastatin10 mg tablet;   Drug: Midazolam 3 mg syrup;   Drug: Dabrafenib 75 mg capsule
18 Completed Evaluating the Pharmacokinetics of High-Dose Rifapentine When Given as a Single Dose or in Divided Doses to Healthy Adults
Condition: Tuberculosis
Intervention: Drug: Rifapentine (RPT)
19 Completed A Repeat Dose Study to Investigate the Interaction of GSK2190915 on the Pharmacokinetics of Rosuvastatin
Condition: Asthma
Interventions: Drug: Rosuvastatin 10 mg;   Drug: GSK2190915 30mg;   Drug: GSK2190915 100mg
20 Completed Investigations on the Influence of Bariatric Surgery on the Metabolism and Absorption of Atorvastatin
Condition: Morbid Obesity
Intervention: Procedure: Bariatric surgery

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Indicates status has not been verified in more than two years