138 studies found for:    P-glycoprotein
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Rank Status Study
1 Recruiting ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma
Condition: Osteosarcoma
Interventions: Drug: Mifamurtide arm;   Other: 3 drugs arm
2 Completed Ontogenesis of the P-Glycoprotein in Human Lymphocytes Influence of HIV and Antiretroviral Therapeutics
Condition: HIV Infections
Intervention:
3 Completed Duration of P-glycoprotein Inhibition After Oral Administration of HM30181AK Tablet
Condition: Healthy
Interventions: Drug: HM30181AK 1mg;   Drug: HM30181AK 5mg;   Drug: HM30181AK 15mg;   Drug: HM30181AK 60mg;   Drug: Loperamide 2mg
4 Unknown  P-glycoprotein Inhibition as Adjunct Treatment for Medically Refractory Epilepsy.
Condition: Epilepsy
Intervention: Drug: Carvedilol-CR
5 Completed A Pharmacokinetic Study to Assess the Influence of P-glycoprotein Inhibition and Simultaneous CYP3A4 and P-glycoprotein Induction on E7080 Pharmacokinetics Following Single Dose Oral Administration of 24 mg E7080 to Healthy Volunteers
Conditions: P-glycoprotein;   Healthy Volunteers
Intervention: Drug: E7080
6 Completed PET Imaging of P-glycoprotein Function Using [11C]dLop
Condition: Healthy
Intervention:
7 Terminated (11C)dLop as a Marker of P-Glycoprotein Function in Patients With Gliomas
Conditions: Low Grade Glioma;   Glioblastoma Multiforme;   Anaplastic Astrocytoma;   Anaplastic Oligodendroglioma;   Oligoastrocytoma
Intervention:
8 Completed
Has Results
Paclitaxel and CBT-1(Registered Trademark) to Treat Solid Tumors
Conditions: Cervical;   Ovarian;   Lung;   Breast;   Renal
Interventions: Drug: paclitaxel;   Drug: CBT-1(Registered Trademark);   Radiation: Tc 99m sestamibi
9 Completed P-glycoprotein Function in Brain Diseases
Conditions: Alzheimer Disease;   Parkinson Disease;   Frontotemporal Lobar Degeneration
Intervention:
10 Completed A Pharmacokinetic Study to Assess the Influence of Simultaneous CYP3A4 and P-glycoprotein Inhibition on E7080 Pharmacokinetics Following Single Dose Oral Administration of 5 mg E7080 to Healthy Volunteers
Condition: Healthy Volunteers
Interventions: Drug: ketoconazole-placebo;   Drug: placebo-ketoconazole
11 Active, not recruiting Efavirenz and Ritonavir on Human Brian P-Glycoprotein
Condition: Drug Effects
Interventions: Drug: [11c] desmethyl-loperamide (dLop);   Drug: Ritonavir;   Drug: Efavirenz
12 Completed Effect of P-glycoprotein Inhibition on Lenalidomide Pharmacokinetics in Healthy Males
Condition: Healthy
Interventions: Drug: Lenalidomide;   Drug: Quinidine;   Drug: Temsirolimus;   Drug: Diphenhydramine
13 Completed A Phase I Study of Infusional Chemotherapy With the P-Glycoprotein Antagonist PSC 833
Conditions: Breast Cancer;   Kidney Neoplasm;   Lymphoma;   Neoplasm Metastasis;   Ovarian Cancer
Intervention: Drug: PSC 833
14 Completed Effects of Tipranavir (With Ritonavir) Capsule and Liquid Formulation on Cytochrome P450 and P-glycoprotein Activity in Healthy Volunteers
Condition: Healthy
Interventions: Drug: Tipranavir capsule;   Drug: Tipranavir solution;   Drug: Ritonavir capsule;   Drug: Caffeine;   Drug: Warfarin sodium;   Drug: Vitamin K;   Drug: Omeprazole;   Drug: Dextromethorphan hydrobromide;   Drug: Midazolam injection;   Drug: Midazolam oral solution;   Drug: Digoxin tablet;   Drug: Digoxin injection
15 Not yet recruiting The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (Caffeine, Warfarin, Omeprazole, Metoprolol and Midazolam) and a P Glycoprotein Substrate (Digoxin)
Condition: Healthy
Interventions: Drug: midazolam;   Drug: caffeine;   Drug: digoxin;   Drug: warfarin;   Drug: omeprazole;   Drug: BI 187004;   Drug: metoprolol
16 Completed Effects of BI 201335 NA on Cytochrome P450 and P-glycoprotein Activity Using a Probe Drug Cocktail in Healthy Volunteers
Condition: Healthy
Interventions: Drug: BI 201335 NA;   Drug: Caffeine;   Drug: Warfarin sodium;   Drug: Vitamin K;   Drug: Omeprazole;   Drug: Dextromethorphan hydrobromide;   Drug: Midazolam HCl solution;   Drug: Midazolam HCl oral syrup;   Drug: Digoxin
17 Completed Vinorelbine and XR9576 to Treat Cancer
Conditions: Breast Cancer;   Cancer;   Lung Cancer;   Ovarian Cancer
Interventions: Drug: Vinorelbine;   Drug: XR9576
18 Completed
Has Results
Surgery Plus Chemotherapy (Doxorubicin, Vincristine and Etoposide), Mitotane, and Tariquidar to Treat Adrenocortical Cancer
Condition: Adrenal Cortex Neoplasms
Intervention: Drug: XR9576 (Tariquidar)
19 Recruiting Brain P-gp and Inflammation in People With Epilepsy
Condition: Epilepsies, Partial
Intervention:
20 Completed
Has Results
Tariquidar and Docetaxel to Treat Patients With Lung, Ovarian, Renal and Cervical Cancer
Conditions: Lung Neoplasms;   Ovarian Neoplasms;   Cervix Neoplasms;   Renal Neoplasms
Interventions: Drug: docetaxel;   Drug: tariquidar;   Other: 99mTc-sestamibi imaging

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Indicates status has not been verified in more than two years