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71 studies found for:    P-glycoprotein

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Rank Status Study
1 Recruiting ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma
Condition: Osteosarcoma
Interventions: Drug: Chemotherapy for positive p-glycoprotein expression;   Other: Chemotherapy for negative p-glycoprotein expression
2 Completed Ontogenesis of the P-Glycoprotein in Human Lymphocytes Influence of HIV and Antiretroviral Therapeutics
Condition: HIV Infections
Intervention:
3 Completed Duration of P-glycoprotein Inhibition After Oral Administration of HM30181AK Tablet
Condition: Healthy
Interventions: Drug: HM30181AK 1mg;   Drug: HM30181AK 5mg;   Drug: HM30181AK 15mg;   Drug: HM30181AK 60mg;   Drug: Loperamide 2mg
4 Unknown † P-glycoprotein Inhibition as Adjunct Treatment for Medically Refractory Epilepsy.
Condition: Epilepsy
Intervention: Drug: Carvedilol-CR
5 Recruiting PET Imaging of P-glycoprotein Function Using [11C]dLop
Condition: Healthy
Intervention:
6 Completed A Phase I Study of Infusional Chemotherapy With the P-Glycoprotein Antagonist PSC 833
Conditions: Breast Cancer;   Kidney Neoplasm;   Lymphoma;   Neoplasm Metastasis;   Ovarian Cancer
Intervention: Drug: PSC 833
7 Terminated (11C)dLop as a Marker of P-Glycoprotein Function in Patients With Gliomas
Conditions: Low Grade Glioma;   Glioblastoma Multiforme;   Anaplastic Astrocytoma;   Anaplastic Oligodendroglioma;   Oligoastrocytoma
Intervention:
8 Recruiting Efavirenz and Ritonavir on Human Brian P-Glycoprotein
Condition: Drug Effects
Interventions: Drug: [11c] desmethyl-loperamide (dLop);   Drug: Ritonavir;   Drug: Efavirenz
9 Completed
Has Results 		Paclitaxel and CBT-1(Registered Trademark) to Treat Solid Tumors
Conditions: Cervical;   Ovarian;   Lung;   Breast;   Renal
Interventions: Drug: paclitaxel;   Drug: CBT-1(Registered Trademark);   Radiation: Tc 99m sestamibi
10 Completed P-glycoprotein Function in Brain Diseases
Conditions: Alzheimer Disease;   Parkinson Disease;   Frontotemporal Lobar Degeneration
Intervention:
11 Completed
Has Results 		Surgery Plus Chemotherapy (Doxorubicin, Vincristine and Etoposide), Mitotane, and Tariquidar to Treat Adrenocortical Cancer
Condition: Adrenal Cortex Neoplasms
Intervention: Drug: XR9576 (Tariquidar)
12 Completed Effect of P-glycoprotein Inhibition on Lenalidomide Pharmacokinetics in Healthy Males
Condition: Healthy
Interventions: Drug: Lenalidomide;   Drug: Quinidine;   Drug: Temsirolimus;   Drug: Diphenhydramine
13 Completed Vinorelbine and XR9576 to Treat Cancer
Conditions: Breast Cancer;   Cancer;   Lung Cancer;   Ovarian Cancer
Interventions: Drug: Vinorelbine;   Drug: XR9576
14 Recruiting Brain P-gp and Inflammation in People With Epilepsy
Condition: Epilepsies, Partial
Intervention:
15 Completed
Has Results 		Tariquidar and Docetaxel to Treat Patients With Lung, Ovarian, Renal and Cervical Cancer
Conditions: Lung Neoplasms;   Ovarian Neoplasms;   Cervix Neoplasms;   Renal Neoplasms
Interventions: Drug: docetaxel;   Drug: tariquidar;   Other: 99mTc-sestamibi imaging
16 Completed
Has Results 		The Role of P-glycoprotein in Sitagliptin Clinical Pharmacology
Condition: Healthy
Interventions: Drug: Sitagliptin;   Drug: atorvastatin
17 Completed A Phase I Study of Infusional Paclitaxel With the P-Glycoprotein Antagonist PSC 833
Conditions: Breast Cancer;   Cancer;   Carcinoma, Renal Cell;   Lymphoma;   Ovarian Cancer
Interventions: Drug: PSC 833;   Drug: paclitaxel
18 Completed Pharmacokinetics of Sublingual Versus Oral Tacrolimus in Patients Awaiting Kidney Transplantation
Condition: Kidney Failure, Chronic
Interventions: Drug: Tacrolimus/Clotrimazole Troche;   Drug: Tacrolimus/Nystatin Suspension
19 Completed The Effect of Thyroid Hormone on Drug Elimination in Cancer Patients
Condition: Thyroid Cancer
Intervention: Procedure: Skin Biopsy
20 Recruiting Cocktail Approach for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood Spot
Condition: Healthy Volunteers
Intervention: Drug: Cocktail probe drugs
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† Indicates status has not been verified in more than two years