90 studies found for:    P-glycoprotein
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Rank Status Study
1 Recruiting ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma
Condition: Osteosarcoma
Interventions: Drug: Mifamurtide arm;   Other: 3 drugs arm
2 Completed A Pharmacokinetic Study to Assess the Influence of P-glycoprotein Inhibition and Simultaneous CYP3A4 and P-glycoprotein Induction on E7080 Pharmacokinetics Following Single Dose Oral Administration of 24 mg E7080 to Healthy Volunteers
Conditions: P-glycoprotein;   Healthy Volunteers
Intervention: Drug: E7080
3 Completed Ontogenesis of the P-Glycoprotein in Human Lymphocytes Influence of HIV and Antiretroviral Therapeutics
Condition: HIV Infections
Intervention:
4 Completed Duration of P-glycoprotein Inhibition After Oral Administration of HM30181AK Tablet
Condition: Healthy
Interventions: Drug: HM30181AK 1mg;   Drug: HM30181AK 5mg;   Drug: HM30181AK 15mg;   Drug: HM30181AK 60mg;   Drug: Loperamide 2mg
5 Recruiting PET Imaging of P-glycoprotein Function Using [11C]dLop
Condition: Healthy
Intervention:
6 Unknown  P-glycoprotein Inhibition as Adjunct Treatment for Medically Refractory Epilepsy.
Condition: Epilepsy
Intervention: Drug: Carvedilol-CR
7 Completed
Has Results
Paclitaxel and CBT-1(Registered Trademark) to Treat Solid Tumors
Conditions: Cervical;   Ovarian;   Lung;   Breast;   Renal
Interventions: Drug: paclitaxel;   Drug: CBT-1(Registered Trademark);   Radiation: Tc 99m sestamibi
8 Completed A Phase I Study of Infusional Chemotherapy With the P-Glycoprotein Antagonist PSC 833
Conditions: Breast Cancer;   Kidney Neoplasm;   Lymphoma;   Neoplasm Metastasis;   Ovarian Cancer
Intervention: Drug: PSC 833
9 Completed A Pharmacokinetic Study to Assess the Influence of Simultaneous CYP3A4 and P-glycoprotein Inhibition on E7080 Pharmacokinetics Following Single Dose Oral Administration of 5 mg E7080 to Healthy Volunteers
Condition: Healthy Volunteers
Interventions: Drug: ketoconazole-placebo;   Drug: placebo-ketoconazole
10 Terminated (11C)dLop as a Marker of P-Glycoprotein Function in Patients With Gliomas
Conditions: Low Grade Glioma;   Glioblastoma Multiforme;   Anaplastic Astrocytoma;   Anaplastic Oligodendroglioma;   Oligoastrocytoma
Intervention:
11 Active, not recruiting Efavirenz and Ritonavir on Human Brian P-Glycoprotein
Condition: Drug Effects
Interventions: Drug: [11c] desmethyl-loperamide (dLop);   Drug: Ritonavir;   Drug: Efavirenz
12 Completed P-glycoprotein Function in Brain Diseases
Conditions: Alzheimer Disease;   Parkinson Disease;   Frontotemporal Lobar Degeneration
Intervention:
13 Completed
Has Results
Surgery Plus Chemotherapy (Doxorubicin, Vincristine and Etoposide), Mitotane, and Tariquidar to Treat Adrenocortical Cancer
Condition: Adrenal Cortex Neoplasms
Intervention: Drug: XR9576 (Tariquidar)
14 Completed Effect of P-glycoprotein Inhibition on Lenalidomide Pharmacokinetics in Healthy Males
Condition: Healthy
Interventions: Drug: Lenalidomide;   Drug: Quinidine;   Drug: Temsirolimus;   Drug: Diphenhydramine
15 Completed Effects of BI 201335 NA on Cytochrome P450 and P-glycoprotein Activity Using a Probe Drug Cocktail in Healthy Volunteers
Condition: Healthy
Interventions: Drug: BI 201335 NA;   Drug: Caffeine;   Drug: Warfarin sodium;   Drug: Vitamin K;   Drug: Omeprazole;   Drug: Dextromethorphan hydrobromide;   Drug: Midazolam HCl solution;   Drug: Midazolam HCl oral syrup;   Drug: Digoxin
16 Completed Vinorelbine and XR9576 to Treat Cancer
Conditions: Breast Cancer;   Cancer;   Lung Cancer;   Ovarian Cancer
Interventions: Drug: Vinorelbine;   Drug: XR9576
17 Recruiting Brain P-gp and Inflammation in People With Epilepsy
Condition: Epilepsies, Partial
Intervention:
18 Recruiting Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycin
Conditions: Drug Interactions;   Pharmacokinetics
Interventions: Drug: Daptomycin;   Drug: Rifampin
19 Completed
Has Results
Tariquidar and Docetaxel to Treat Patients With Lung, Ovarian, Renal and Cervical Cancer
Conditions: Lung Neoplasms;   Ovarian Neoplasms;   Cervix Neoplasms;   Renal Neoplasms
Interventions: Drug: docetaxel;   Drug: tariquidar;   Other: 99mTc-sestamibi imaging
20 Terminated Relative Bioavailability of Dabigatran Etexilate Capsules With and Without Quinidine Sulfate Tablets and to Measure the Effect of Quinidine on the Absorption of Fexofenadine in Healthy Male and Female Volunteers
Condition: Healthy
Interventions: Drug: Dabigatran etexilate capsules;   Drug: Quinidine sulfate tablets;   Drug: Fexofenadine tablets

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Indicates status has not been verified in more than two years