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79 studies found for:    MEK Inhibitor AZD-6244
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Rank Status Study
1 Completed A Randomized, Open Label Study to Compare the Current Phase II and Planned Phase III Capsule Formulation of AZD6244
Condition: Healthy Volunteers
Interventions: Drug: AZD6244 Dosing Period 1;   Drug: AZD6244 Dosing Period 2;   Drug: AZD6244 Dosing Period 3;   Drug: AZD6244 Dosing Period 4
2 Completed Reacquisition of Radioactive Iodine (RAI) Uptake of RAI-Refractory Metastatic Thyroid Cancers by Pretreatment With the Selective MEK Inhibitor AZD6244
Condition: Thyroid Cancer
Intervention: Biological: AZD6244
3 Completed To Assess the Effect of Itraconazole and Fluconazole on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers
Condition: Solid Tumours
Interventions: Drug: selumetinib;   Drug: itraconazole;   Drug: fluconazole
4 Completed To Assess the Effect of Rifampicin on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers
Condition: Solid Tumours
Interventions: Drug: selumetinib;   Drug: rifampicin
5 Completed To Assess the Effects of Single Oral Dose of Selumetinib [AZD6244; ARRY-142886] [Hyd-Sulfate]), on QTc Interval in Healthy Male Volunteers
Condition: Solid Tumours
Interventions: Drug: Selumetinib;   Drug: Moxifloxacin;   Drug: selumetinib
6 Completed A Study to Assess the Absolute Bioavailability of Oral Selumetinib in Healthy Male Volunteers.
Condition: Healthy Volunteers Bioavailability Study
Interventions: Drug: selumetinib 75mg single dose;   Other: [14C] selumetinib IV solution
7 Recruiting A Study of Selumetinib in Patients With Kaposi's Sarcoma
Condition: AIDS-related Kaposi's Sarcoma
Intervention: Drug: Selumetinib
8 Active, not recruiting Selumetinib and Cixutumumab in Treating Patients With Advanced Solid Malignancies
Condition: Adult Solid Neoplasm
Interventions: Drug: Selumetinib;   Biological: Cixutumumab;   Other: Pharmacological Study;   Other: Laboratory Biomarker Analysis
9 Recruiting MEK Inhibitor and Thoracic Radiotherapy Trial
Condition: Non Small Cell Lung Cancer
Intervention: Drug: AZD6244
10 Active, not recruiting A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)
Conditions: Breast Cancer;   Breast Neoplasms;   Colon Cancer;   Colonic Cancer;   Colon Neoplasms;   Lung Cancer;   Melanoma;   Kidney Cancer
Interventions: Drug: AZD6244;   Drug: Dacarbazine;   Drug: Erlotinib;   Drug: Docetaxel;   Drug: Temsirolimus
11 Completed Randomised Study to Compare the Efficacy of AZD6244 vs TMZ
Condition: Melanoma
Interventions: Drug: AZD6244;   Drug: Temozolomide
12 Completed Selumetinib and Cetuximab in Treating Patients With Refractory Solid Tumors
Conditions: Recurrent Colon Cancer;   Recurrent Rectal Cancer;   Stage IVA Colon Cancer;   Stage IVA Rectal Cancer;   Stage IVB Colon Cancer;   Stage IVB Rectal Cancer;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: selumetinib;   Biological: cetuximab;   Other: laboratory biomarker analysis;   Other: pharmacological study
13 Completed AZD6244 (Selumetinib, ARRY142886) J-BTC Phase 1 Study
Condition: Inoperable Locally Advanced or Metastatic Biliary Tract Cancer
Interventions: Drug: Cisplatin;   Drug: Gemcitabine;   Drug: Selumetinib
14 Completed To Assess the Effect of Food on the Pharmacokinetics of Selumetinib (AZD6244; ARRY-142886) (Hyd-Sulfate) in Healthy Male Volunteers
Condition: Solid Tumours
Intervention: Drug: selumetinib (oral)
15 Recruiting Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma
Conditions: Childhood Cerebellar Astrocytoma;   Childhood Cerebral Astrocytoma;   Childhood Mixed Glioma;   Childhood Pilocytic Astrocytoma;   Neurofibromatosis Type 1;   Recurrent Childhood Anaplastic Oligodendroglioma;   Recurrent Childhood Brain Stem Glioma;   Recurrent Childhood Cerebellar Astrocytoma;   Recurrent Childhood Cerebral Astrocytoma;   Recurrent Childhood Oligodendroglioma;   Recurrent Childhood Pilocytic Astrocytoma;   Recurrent Childhood Visual Pathway Glioma
Interventions: Drug: Selumetinib;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study
16 Recruiting Selumetinib and Cyclosporine in Treating Patients With Advanced Solid Tumors or Advanced or Metastatic Colorectal Cancer
Conditions: Adult Solid Neoplasm;   Recurrent Colon Carcinoma;   Recurrent Rectal Carcinoma;   Stage IIIA Colon Cancer;   Stage IIIA Rectal Cancer;   Stage IIIB Colon Cancer;   Stage IIIB Rectal Cancer;   Stage IIIC Colon Cancer;   Stage IIIC Rectal Cancer;   Stage IVA Colon Cancer;   Stage IVA Rectal Cancer;   Stage IVB Colon Cancer;   Stage IVB Rectal Cancer
Interventions: Drug: Selumetinib;   Drug: Cyclosporine;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study
17 Terminated Selumetinib in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma
Condition: Recurrent Adult Diffuse Large Cell Lymphoma
Interventions: Drug: selumetinib;   Other: laboratory biomarker analysis
18 Completed Dose-escalation Study to Assess Selumetinib Safety, Tolerability and PK
Condition: Healthy Volunteers Pharmacokinetic Study
Intervention: Drug: Selumetinib
19 Unknown  AZD6244 and Sorafenib in Advanced Hepatocellular Carcinoma
Conditions: Unresectable Hepatocellular Carcinoma;   Liver Cancer
Intervention: Drug: AZD6244 and sorafenib
20 Active, not recruiting Selumetinib in Cancers With BRAF Mutations
Condition: Adult Solid Neoplasm
Interventions: Drug: Selumetinib;   Other: Laboratory Biomarker Analysis

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