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1 Recruiting A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 Diabetes
Conditions: Type 2 Diabetes;   Comparative Effectiveness of Glycemia-lowering Medications
Interventions: Drug: Sulfonylurea (glimepiride);   Drug: DPP-4 inhibitor (sitagliptin);   Drug: GLP-1 receptor agonist (liraglutide);   Drug: Insulin (glargine)
2 Terminated Study of CryoSpray Ablation of Low Grade or High Grade Dysplasia Within Barrett's Esophagus
Conditions: Barrett's Esophagus;   High Grade Dysplasia;   Low Grade Dysplasia
Intervention: Device: CryoSpray Ablation System (510(k) NO: K070893)
3 Completed
Has Results
A Randomized Study of Iodine-131 Anti-b1 Antibody Versus Anti-b1 Antibody in Chemotherapy-relapsed/Refractory Low-grade or Transformed Low-grade Non-Hodgkin's Lymphoma (NHL)
Condition: Lymphoma, Non-Hodgkin
Intervention: Biological: Iodine-131 Anti-B1 Antibody Versus Anti-B1 Antibody in Chemotherapy-Relapsed/Refractory Low-Grade or Transformed Low-Grade Non-Hodgkin's Lymphoma (NHL)
4 Completed
Has Results
Pivotal Study of Iodine I 131 Tositumomab for Chemotherapy-refractory Low-grade or Transformed Low-grade B-cell Non-Hodgkin's Lymphoma
Condition: Lymphoma, Non-Hodgkin
Intervention: Biological: Tositumomab and Iodine I 131 Tositumomab
5 Completed Genetic Risk Assessment of Defibrillator Events
Conditions: Sudden Cardiac Death;   Arrhythmias;   Congestive Heart Failure;   Cardiomyopathy
Intervention:
6 Active, not recruiting A Study of Bevacizumab Therapy in Patients With Newly Diagnosed High-Grade Gliomas and Diffuse Intrinsic Pontine Gliomas
Conditions: Newly Diagnosed High-Grade Gliomas;   Diffuse Intrinsic Pontine Glioma
Interventions: Drug: Temozolomide;   Drug: Bevacizumab;   Drug: Irinotecan
7 Active, not recruiting External Beam Radiation Therapy and Cetuximab Followed by Irinotecan and Cetuximab for Children and Young Adults With Newly Diagnosed Diffuse Pontine Tumors and High-Grade Astrocytomas
Condition: Brain Cancer
Intervention: Other: cetuximab in conjunction with external beam radiation therapy, followed by cetuximab and irinotecan
8 Recruiting Radiofrequency Ablation for Barrett Oesophagus With Low Grade Dysplasia
Conditions: Barrett Oesophagus;   Low Grade Dysplasia
Interventions: Procedure: Endoscopic radiofrequency ablation;   Other: Endoscopic surveillance
9 Enrolling by invitation Permeability Map to Distinguish Progression From Pseudoprogression in High-Grade Glioma
Condition: High Grade Glioma
Intervention:
10 Completed
Has Results
Phase II Imatinib + Hydroxyurea in Treatment of Patients With Recurrent/Progressive Grade II Low-Grade Glioma (LGG)
Conditions: Glioblastoma;   Gliosarcoma
Intervention: Drug: Imatinib Mesylate & Hydroxyurea
11 Completed Rituximab and Dexamethasone in Treating Patients With Low-Grade Non-Hodgkin Lymphoma
Conditions: Contiguous Stage II Grade 1 Follicular Lymphoma;   Contiguous Stage II Grade 2 Follicular Lymphoma;   Contiguous Stage II Marginal Zone Lymphoma;   Cutaneous B-cell Non-Hodgkin Lymphoma;   Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue;   Nodal Marginal Zone B-cell Lymphoma;   Noncontiguous Stage II Grade 1 Follicular Lymphoma;   Noncontiguous Stage II Grade 2 Follicular Lymphoma;   Noncontiguous Stage II Marginal Zone Lymphoma;   Recurrent Grade 1 Follicular Lymphoma;   Recurrent Grade 2 Follicular Lymphoma;   Recurrent Marginal Zone Lymphoma;   Splenic Marginal Zone Lymphoma;   Stage I Grade 1 Follicular Lymphoma;   Stage I Grade 2 Follicular Lymphoma;   Stage I Marginal Zone Lymphoma;   Stage III Grade 1 Follicular Lymphoma;   Stage III Grade 2 Follicular Lymphoma;   Stage III Marginal Zone Lymphoma;   Stage IV Grade 1 Follicular Lymphoma;   Stage IV Grade 2 Follicular Lymphoma;   Stage IV Marginal Zone Lymphoma;   Waldenstrom Macroglobulinemia
Interventions: Other: pharmacological study;   Biological: rituximab;   Drug: dexamethasone;   Other: laboratory biomarker analysis
12 Terminated
Has Results
Preoperative Thalidomide With Radiation Therapy For Patients With Low-Grade Primary Soft Tissue Sarcoma or Thalidomide With Radiation Therapy and Chemotherapy For Patients With High-Grade or Intermediate-Grade Primary Soft Tissue Sarcoma of the Arm, Leg, or Body Wall
Conditions: Recurrent Adult Soft Tissue Sarcoma;   Stage I Adult Soft Tissue Sarcoma;   Stage II Adult Soft Tissue Sarcoma;   Stage III Adult Soft Tissue Sarcoma
Interventions: Drug: doxorubicin hydrochloride;   Drug: ifosfamide;   Drug: dacarbazine;   Biological: filgrastim;   Radiation: radiation therapy;   Drug: thalidomide;   Procedure: therapeutic conventional surgery;   Other: laboratory biomarker analysis
13 Active, not recruiting
Has Results
Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma
Conditions: Childhood High-grade Cerebral Astrocytoma;   Childhood Oligodendroglioma;   Childhood Spinal Cord Neoplasm;   Recurrent Childhood Brain Stem Glioma;   Recurrent Childhood Ependymoma;   Recurrent Childhood Medulloblastoma
Interventions: Biological: bevacizumab;   Drug: irinotecan hydrochloride;   Radiation: fludeoxyglucose F 18
14 Completed
Has Results
Cidofovir in Treating HIV-Infected Patients With High-Grade Squamous Intraepithelial Lesions of the Skin Near the Anus
Conditions: Anal Cancer;   Precancerous Condition
Interventions: Drug: cidofovir;   Genetic: DNA methylation analysis;   Genetic: gene expression analysis;   Genetic: polymerase chain reaction;   Procedure: biopsy;   Procedure: histopathologic examination
15 Completed Study of Natural History of Human Papillomavirus (HPV) Infections in Adult Women With Recurrent Conizations in Norway
Conditions: Microinvasive Carcinomas and Invasive Cervical Cancer;   High Grade Cervical Lesions
Intervention: Procedure: Cancer Registry of Norway (database)
16 Active, not recruiting Erlotinib and Radiation Therapy in Treating Young Patients With Newly Diagnosed Glioma
Condition: Brain and Central Nervous System Tumors
Intervention: Drug: Erlotinib hydrochloride
17 Completed ZD6474 to Treat Advanced Brain Cancer in Patients
Conditions: Recurrent High-Grade Gliomas;   Progressive Low-Grade Gliomas;   Malignant Gliomas
Interventions: Drug: Steroids;   Drug: ZD6474
18 Recruiting Study to Evaluate the Effects of Imiquimod and Tumor Lysate Vaccine Immunotherapy in Adults With High Risk or Recurrent/Post-Chemotherapy WHO Grade II Gliomas
Conditions: High Risk WHO Grade II Glioma;   Recurrent/Post-Chemotherapy WHO Grade II Glioma
Interventions: Biological: Tumor Lysate Vaccine;   Drug: Imiquimod
19 Active, not recruiting ABT-888 With Cyclophosphamide in Refractory BRCA-Positive Ovarian, Primary Peritoneal or Ovarian High-Grade Serous Carcinoma, Fallopian Tube Cancer, Triple-Negative Breast Cancer, and Low-Grade Non-Hodgkin s Lymphoma
Conditions: Ovarian;   Primary Peritoneal;   Serous Carcinoma;   Triple-Negative Breast;   Fallopian Tube
Interventions: Drug: ABT-888 with Cyclophospharmide;   Drug: Cyclophosphamide
20 Recruiting PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children
Conditions: Pediatric Recurrent Progressive Low-grade Gliomas;   Pediatric Progressive Low-grade Gliomas
Intervention: Drug: Everolimus

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